c-Met-IN-13
c-Met-IN-13 is a potent c-Met inhibitor with an IC50 value of 2.43 nM. c-Met-IN-13 shows excellent cytotoxicity for cancer cells. c-Met-IN-13 shows antiproliferative activity in a concentration- and time- dependent manner. c-Met-IN-13 has the potential for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 2377724-93-9
- Formula: C30H28F2N2O6
- Molecular Weight:550.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | IC50 |
0.2 μM
Compound: 10m
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Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
|
[PMID: 32200199] |
| MDA-MB-231 | IC50 |
0.42 μM
Compound: 10m
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Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
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[PMID: 32200199] |
| MKN-45 | IC50 |
0.26 μM
Compound: 10m
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Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
|
[PMID: 32200199] |
| NCI-H460 | IC50 |
0.14 μM
Compound: 10m
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Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
|
[PMID: 32200199] |
c-Met-IN-13 (compound 10m) shows cytotoxic activities with IC50s of 0.14, 0.20, 0.26 µM for H460, HT-29, MKN-45, respectively[1].
c-Met-IN-13 shows tyrosine kinases selectively with IC50s of 4.42, 6.15, 18.64, 295, 540, >10000, 2.43 nM for c-kit, Flt-3,Ron, VEGFR-2, Flt-4, EGFR, C-Met, respectively[1].
c-Met-IN-13 (0-300 µg/ml; 72 h) shows antiproliferative activity in a concentration and time dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2377724-93-9
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Molecular Weight 550.55
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Formula C30H28F2N2O6
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SMILES
O=C(OC(C(C)(C)C)C(NC1=CC=C(OC2=CC=NC3=CC(OC)=C(OC)C=C23)C(F)=C1)=O)C4=CC=C(F)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
c-Met-IN-13 Related Classifications
HY-150576 Related Classifications
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