c-Met-IN-28
c-Met-IN-28 is a type III allosteric inhibitor of c-MET, with pKi values of 7.4 (WT) and 7.1 (D1228V), and IC50 values of 37 nM (WT) and 72 nM (D1228V) against human c-MET. c-Met-IN-28 can be used for research on c-MET-driven cancers.
For research use only. We do not sell to patients.
- Formula: C25H20FN3O2
- Molecular Weight:413.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
c-Met-IN-28 (Compound 20) (10 μM ATP) potently inhibits wild-type (WT) c-MET in the ADP-Glo biochemical kinase assay, with an IC50 of 37 nM; it also inhibits the D1228V mutant c-MET, with an IC50 of 72 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 413.44
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Formula C25H20FN3O2
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SMILES
O=C1N[C@H](CC2=CC=CC=C2)C3=C1C=NC(C4=CC(F)=CC(C5=CN=C(CC)O5)=C4)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
c-Met-IN-28 Related Classifications
HY-183672 Related Classifications
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