Antitumor agent-152
Antitumor agent-152 (Compound 5) is a specific substrate and inhibitor of deoxycytidine kinase (dCK) with anticancer activity. Antitumor agent-152 can inhibit the uptake of 3H-dC in L1210 leukemia cells with an IC50 value of 1.12 μM.
For research use only. We do not sell to patients.
- CAS No.: 1209784-87-1
- Formula: C17H19N5O2S2
- Molecular Weight:389.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L1210 | IC50 |
1.12 μM
Compound: 5
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Inhibition of dCK in mouse L1210 cells assessed as inhibition of tritiated deoxycytidine [3H]-dC uptake
Inhibition of dCK in mouse L1210 cells assessed as inhibition of tritiated deoxycytidine [3H]-dC uptake
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[PMID: 23947754] |
Chemical Information
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CAS No. 1209784-87-1
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Molecular Weight 389.50
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Formula C17H19N5O2S2
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SMILES
NC1=NC(SCC2=CSC(C3=CC=C(OCC)C(OC)=C3)=N2)=NC(N)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-152 Related Classifications
HY-W194107 Related Classifications
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