Baiap2 - brain-specific angiogenesis inhibitor 1-associated protein 2 Gene

Also Known as IRSp53

Species: Mus musculus

Gene Type: protein coding
Gene ID: 108100

Summary

Predicted to enable several functions, including PDZ domain binding activity; identical protein binding activity; and scaffold protein binding activity. Involved in several processes, including actin filament organization; modification of synaptic structure, modulating synaptic transmission; and regulation of cell shape. Acts upstream of or within dendrite development and regulation of synaptic plasticity. Located in Schaffer collateral - CA1 synapse and neuron projection. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; attention deficit hyperactivity disorder; and autism spectrum disorder. Orthologous to human BAIAP2 (BAR/IMD domain containing adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Baiap2 Products (3)

mRNA Protein Name
NM_001037754.3 NP_001032843.1 brain-specific angiogenesis inhibitor 1-associated protein 2 isoform c
NM_001037755.3 NP_001032844.2 brain-specific angiogenesis inhibitor 1-associated protein 2 isoform a
NM_130862.4 NP_570932.2 brain-specific angiogenesis inhibitor 1-associated protein 2 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10814512 MGI
Biological Process GO Annotation Evidence References Source
involved in actin crosslink formation IMP
IMP: Inferred from mutant phenotype
17115031 MGI
acts upstream of or within actin filament bundle assembly IGI
IGI: Inferred from genetic interaction
19208628 MGI
involved in actin filament bundle assembly IMP
IMP: Inferred from mutant phenotype
17115031 MGI
acts upstream of or within dendrite development IMP
IMP: Inferred from mutant phenotype
19208628 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
19193906 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
19193906 MGI
involved in regulation of cell shape IMP
IMP: Inferred from mutant phenotype
17115031 MGI
acts upstream of or within regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
19208628 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
19193906 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
19193906 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
21795692 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

brain-specific angiogenesis inhibitor 1-associated protein 2

  • BAI-associated protein 2

  • BAI1-associated protein 2

  • insulin receptor substrate p53

  • insulin receptor substrate protein of 53 kDa

  • insulin receptor tyrosine kinase 53 kDa substrate

Baiap2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Baiap2 Q8BKX1 Diaph1 Mus musculus O08808
Far-WB
10814512
Intra
Baiap2 Q8BKX1 Diaph1 Mus musculus O08808
Y2H
10814512
Intra
Baiap2 Q8BKX1 Dlg4 Mus musculus Q62108
Anti Bait CoIP
19455133
Intra
Baiap2 Q8BKX1 Iqsec2 Mus musculus A4GZ26
Pull Down
19083995
Intra
Baiap2 Q8BKX1 Iqsec2 Mus musculus A4GZ26
Y2H
19083995
Intra
Baiap2 Q8BKX1 Iqsec2 Mus musculus A4GZ26
Anti Bait CoIP
19083995
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01353 BAIAP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01354 BAIAP2L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01355 BAIAP2L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21826 Baiap2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28343 Baiap2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Baiap2 NCBI NCBI:10458