RCOR1 - REST corepressor 1 Gene

Also Known as RCOR; COREST

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23186

About RCOR1

Cytogenetic location: 14q32.31-q32.32 Genomic coordinates (GRCh38): 14:102,592,649-102,730,561 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues and 5 paralogues. Ubiquitous expression in bone marrow (RPKM 19.5), esophagus (RPKM 14.2) and 25 other tissues.

Summary

This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011]

RCOR1 Products (1)

mRNA Protein Name
NM_015156.4 NP_055971.2 REST corepressor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10449787 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10449787 GOA
Cellular Component GO Annotation Evidence References Source
part of DNA repair complex IDA
IDA: Inferred from direct assay
24217620 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10734093 GOA
part of transcription repressor complex IDA
IDA: Inferred from direct assay
10734093 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RCOR1 Protein Structure

ELM2

ELM2: ELM2 domain (102 - 156)

Myb_DNA-binding

Myb_DNA-binding: Myb-like DNA-binding domain (382 - 425)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 482 a.a.
Protein Preferred Names Protein Names

REST corepressor 1

RCOR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RCOR1 Q9UKL0 ZNF516 Homo sapiens Q92618
Anti Tag CoIP
33961781
Intra
RCOR1 Q9UKL0 HDAC1 Homo sapiens Q13547
Anti Bait CoIP
12192000
Intra
RCOR1 Q9UKL0 HDAC1 Homo sapiens Q13547
Anti Bait CoIP
17939992
Intra
RCOR1 Q9UKL0 SMARCE1 Homo sapiens Q969G3-2
Y2H
12192000
Intra
RCOR1 Q9UKL0 KDM1A Homo sapiens O60341
Anti Tag CoIP
33961781
Intra
RCOR1 Q9UKL0 KDM1A Homo sapiens O60341
Anti Bait CoIP
19703393
Cross: Cross-species interaction Intra: Intraspecies interaction

RCOR1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82068 CoREST Antibody (YA1813) WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Joubert Syndrome 1

  • Joubert Syndrome

  • Jbts

  • Cerebellooculorenal Syndrome 1

  • JBTS1

  • Joubert-Boltshauser Syndrome

  • Cerebelloparenchymal Disorder Iv

  • Cpd4

  • Cors1

  • Joubert Syndrome And Related Disorders

  • Jsrd

  • Familial Aplasia Of The Vermis

  • Joubert Syndrome Related Disorders

  • Js

  • Cerebellar Vermis Agenesis

  • Cerebelloparenchymal Disorder 4

  • Agenesis Of Cerebellar Vermis

  • Cerebello-Oculo-Renal Syndrome

  • Cors

  • Joubert-Bolthauser Syndrome

  • Cpd Iv

  • Classic Joubert Syndrome

  • Joubert Syndrome Type A

  • Pure Joubert Syndrome

  • Cerebello-Oculo-Renal Syndrome 1

  • Joubert Syndrome-1

  • Joubert Syndrome, Type 1

  • Joubert'S Syndrome
Medulloblastoma

  • MDB

  • Cpnet

  • Localized Primitive Neuroectodermal Tumor

  • Classic Medulloblastoma

  • Medulloblastoma Predisposition Syndrome

  • Medulloblastoma, Somatic

  • Brain Medulloblastoma

  • Cns Pnet

  • Infratentorial Primitive Neuroectodermal Tumor

  • Neuroectodermal Tumors, Primitive

  • Medulloblastomas

  • Desmoplastic Medulloblastoma

  • Medulloblastoma, With Extensive Nodularity

  • Medulloblastoma Of Unspecified Site

  • Medullomyoblastoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12362 RXRB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11791 RCOR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21729 Rcor1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22773 Rcor2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28246 Rcor1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RCOR1 VGNC VGNC:45446
Rattus norvegicus RCOR1 RGD RGD:7505493
Mus musculus RCOR1 MGD MGI:106340
Bos taurus RCOR1 VGNC VGNC:33834
Macaca mulatta RCOR1 VGNC VGNC:76752
Felis catus RCOR1 VGNC VGNC:64551
Others RCOR1 NCBI