Dock5 - dedicator of cytokinesis 5 Gene

Also Known as lr2; rlc; E130320D18; 1110060D06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 68813

Summary

Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of vascular associated smooth muscle contraction; positive regulation of cell migration; and positive regulation of substrate adhesion-dependent cell spreading. Located in cytoplasm. Is expressed in cap mesenchyme and renal cortex. Orthologous to human DOCK5 (dedicator of cytokinesis 5). [provided by Alliance of Genome Resources, Apr 2022]

Dock5 Products (1)

mRNA Protein Name
NM_177780.3 NP_808448.2 dedicator of cytokinesis protein 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
18396277 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
27505886 MGI
Biological Process GO Annotation Evidence References Source
involved in Rac protein signal transduction IDA
IDA: Inferred from direct assay
27505886 MGI
acts upstream of or within bone remodeling IMP
IMP: Inferred from mutant phenotype
27505886 MGI
acts upstream of or within podosome assembly IMP
IMP: Inferred from mutant phenotype
27505886 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18396277 MGI
located in podosome IDA
IDA: Inferred from direct assay
27505886 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dedicator of cytokinesis protein 5

  • lens rupture 2

  • lens rupture protein 2

  • rupture of lens cataract protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110100 CPYPP Inhibitor 99.80% Unkown
HY-171274 DOCK5-IN-1 Inhibitor 98.13% Unkown
HY-164587 E197 Inhibitor 99.91% Unkown
HY-RS03927 DOCK5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17827 Dock5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24295 Dock5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dock5 NCBI NCBI:80005