DOCK5 - dedicator of cytokinesis 5 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80005

About DOCK5

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:25,184,689-25,415,711 (from NCBI)

This gene has 12 transcripts (splice variants), 222 orthologues and 10 paralogues. Ubiquitous expression in spleen (RPKM 6.2), small intestine (RPKM 5.7) and 25 other tissues.

Summary

This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family act as guanine nucleotide exchange factors for small Rho family G proteins. The protein encoded by this gene is thought to associate with adaptors CRK and CRKL, and function in regulation of intestinal epithelial cell spreading and migration on Collagen IV. Similar proteins in mouse and zebrafish also function in myoblast fusion. [provided by RefSeq, Oct 2016]

DOCK5 Products (2)

mRNA Protein Name
NM_001322810.2 NP_001309739.1 dedicator of cytokinesis protein 5 isoform 2
NM_024940.8 NP_079216.4 dedicator of cytokinesis protein 5 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19004829 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of vascular associated smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
22158624 GOA
involved in positive regulation of epithelial cell migration IMP
IMP: Inferred from mutant phenotype
19004829 GOA
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
19004829 GOA
involved in positive regulation of vascular associated smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
22158624 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
19004829 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DOCK5 Protein Structure

SH3_1

SH3_1: SH3 domain (14 - 60)

DOCK-C2

DOCK-C2: C2 domain in Dock180 and Zizimin proteins (439 - 637)

DHR-2

DHR-2: Dock homology region 2 (1452 - 1634)

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  • 1500
  • 1870 a.a.
Protein Preferred Names Protein Names

dedicator of cytokinesis protein 5

Related Diseases

Diseases Alias
Immunodeficiency 40

  • Dock2 Deficiency

  • IMD40

  • Immunodeficiency, Type 40
Li-Fraumeni Syndrome 1

  • Lfs1
Li-Fraumeni Syndrome 2

  • LFS2

  • Li-Fraumeni Syndrome, Type 2

  • Li-Fraumeni Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110100 CPYPP Inhibitor 99.80% Unkown
HY-171274 DOCK5-IN-1 Inhibitor 98.13% Unkown
HY-164587 E197 Inhibitor 99.91% Unkown
HY-RS03927 DOCK5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17827 Dock5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24295 Dock5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DOCK5 MGD MGI:2652871
Rattus norvegicus DOCK5 RGD RGD:1306872
Bos taurus DOCK5 VGNC VGNC:28159
Felis catus DOCK5 VGNC VGNC:61574
Macaca mulatta DOCK5 VGNC VGNC:83995
Canis familiaris DOCK5 VGNC VGNC:40049
Others DOCK5 NCBI