JAK2-IN-5
JAK2-IN-5 (Compound 13) is a selective JAK kinase inhibitor, with an IC50 of 0.078 μM against JAK-2 and an IC50 of 0.206 μM against JAK-2V617F. JAK2-IN-5 can be used for the research of myeloproliferative disorders.
For research use only. We do not sell to patients.
- CAS No.: 1110502-30-1
- Formula: C17H20N4O2S
- Molecular Weight:344.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
JAK2 0.078 μM (IC50) |
JAK2V617F 0.206 μM (IC50) |
In Vitro
JAK2-IN-5 potently inhibits JAK-2 WT kinase with an IC50 of 78 nM and a ligand efficiency of 0.41 kcal mol-1[1].
JAK2-IN-5 inhibits JAK-2V617F mutant kinase with an IC50 of 206 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1110502-30-1
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Molecular Weight 344.43
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Formula C17H20N4O2S
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SMILES
O=S(=O)(NC(C)(C)C)C=1C=CC(=CC1)C2=CC=C3NN=C(N)C3=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JAK2-IN-5 Related Classifications
HY-136734 Related Classifications
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