Bioactive Compound Series
Bioactive compounds exert a wide range of biological effects by interacting with molecular targets and modulating cellular processes. They are valuable tools for drug discovery, target validation, and mechanistic research.
MedChemExpress (MCE) offers a comprehensive portfolio of bioactive compounds for high-throughput screening (HTS), high-content screening (HCS), and drug repurposing. The collection includes over 30,000 compounds targeting more than 1,500 proteins or protein families across 20+ signaling pathways.
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Novel Bioactive Compound Library2,856 compoundsHY-L111
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Targeted Diversity Library2,293 compoundsHY-L099
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Bioactive Compound Library Plus32,925 compoundsHY-L001P
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Bioactive Compound Library27,212 compoundsHY-L001
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Multi-Target Compound Library7,469 compoundsHY-L176
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Bioactive Compound Library Max30,268 compoundsHY-L181
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Withdrawn Drug Compound Library232 compoundsHY-L140
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EMA-Approved Drug Library730 compoundsHY-L116
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Pediatric Drug Library714 compoundsHY-L104
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Drug Repurposing Compound Library5,161 compoundsHY-L035
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Drug Repurposing Compound Library Plus6,158 compoundsHY-L035P
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Clinical Compound Library2,579 compoundsHY-L026
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Clinical Compound Library Plus3,310 compoundsHY-L026P
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NMPA-Approved Drug Library1,534 compoundsHY-L053
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FDA-Approved Drug Library Mini3,239 compoundsHY-L022M
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FDA-Approved Drug Library3,239 compoundsHY-L022
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FDA-Approved Drug Library Plus3,666 compoundsHY-L022P
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FDA Approved & Pharmacopeial Drug Library3,751 compoundsHY-L066
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Off-patent Drug Library2,924 compoundsHY-L141
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FDA-Approved Anticancer Drug Library1,545 compoundsHY-L122
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Classic FDA-Approved Drug Library168 compoundsHY-L261
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Gut Microbial Metabolite Library473 compoundsHY-L078
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Human Metabolite Library6,774 compoundsHY-L123
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Human Endogenous Metabolite Compound Library760 compoundsHY-L030
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Microbial Metabolite Library943 compoundsHY-L084
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Mouse Metabolite Compound Library328 compoundsHY-L217
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Amino Acid Metabolite Compound Library193 compoundsHY-L227
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Mass Spectrometry Human Metabolite Library6,106 compoundsHY-L215
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Nucleotide Metabolite Compound Library82 compoundsHY-L234
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Mass Spectrometry Human Endogenous Metabolite Library661 compoundsHY-L207
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Lipid Metabolite Compound Library144 compoundsHY-L228
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Membrane Receptor-targeted Compound Library7,190 compoundsHY-L150
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Membrane Protein-targeted Compound Library8,052 compoundsHY-L149
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Coagulation and Anti-coagulation Compound Library1,540 compoundsHY-L136
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Osteogenesis Compound Library999 compoundsHY-L131
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Chemokine Compound Library262 compoundsHY-L132
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Nuclear Receptor Compound Library1,097 compoundsHY-L126
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5-HT Receptor Compound Library433 compoundsHY-L121
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GABA Receptor Compound Library210 compoundsHY-L120
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Potassium Channel Compound Library340 compoundsHY-L119
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Sodium Channel Blocker Library200 compoundsHY-L118
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Calcium Channel Blocker Library227 compoundsHY-L117
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Oxygen Sensing Compound Library4,368 compoundsHY-L045
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Wnt/Hedgehog/Notch Compound Library661 compoundsHY-L020
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TGF-beta/Smad Compound Library463 compoundsHY-L018
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Stem Cell Signaling Compound Library2,970 compoundsHY-L017
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Protein Tyrosine Kinase Compound Library1,705 compoundsHY-L016
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PI3K/Akt/mTOR Compound Library1,168 compoundsHY-L015
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NF-κB Signaling Compound Library1,840 compoundsHY-L014
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Transcription Factor-Targeted Library2,607 compoundsHY-L090
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Neuronal Signaling Compound Library3,989 compoundsHY-L013
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Membrane Transporter/Ion Channel Compound Library2,303 compoundsHY-L011
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MAPK Compound Library1,182 compoundsHY-L010
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Kinase Inhibitor Library4,033 compoundsHY-L009
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Phosphatase Inhibitor Library185 compoundsHY-L081
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JAK/STAT Compound Library747 compoundsHY-L008
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Immunology/Inflammation Compound Library8,743 compoundsHY-L007
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Histone Modification Research Compound Library935 compoundsHY-L024
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Protein-protein Interaction Inhibitor Library836 compoundsHY-L109
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GPCR/G Protein Compound Library3,545 compoundsHY-L006
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Epigenetics Compound Library2,048 compoundsHY-L005
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Cell Cycle/DNA Damage Compound Library3,557 compoundsHY-L004
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Ubiquitination Compound Library507 compoundsHY-L050
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Reprogramming Compound Library3,257 compoundsHY-L039
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Differentiation Inducing Compound Library2,617 compoundsHY-L038
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Antioxidant Compound Library2,528 compoundsHY-L037
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Neurotransmitter Receptor Compound Library2,611 compoundsHY-L062
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Cytoskeleton Compound Library2,345 compoundsHY-L060
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Angiogenesis-Related Compound Library3,715 compoundsHY-L088
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Mitochondria-Targeted Compound Library1,197 compoundsHY-L089
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Endoplasmic Reticulum Stress Compound Library384 compoundsHY-L054
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Exosomes Compound Library57 compoundsHY-L072
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Mechanoreceptors Compound Library395 compoundsHY-L095
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TCA Cycle Compound Library73 compoundsHY-L148
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Cuproptosis Compound Library457 compoundsHY-L133
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Metabolism/Protease Compound Library7,420 compoundsHY-L012
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Glycolysis Compound Library1,402 compoundsHY-L058
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Autophagy Compound Library2,100 compoundsHY-L029
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Apoptosis Compound Library3,690 compoundsHY-L003
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Ferroptosis Compound Library1,276 compoundsHY-L051
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Glucose Metabolism Compound Library1,805 compoundsHY-L092
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Lipid Metabolism Compound Library1,036 compoundsHY-L091
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Glutamine Metabolism Compound Library1,868 compoundsHY-L064
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Pyroptosis Compound Library2,069 compoundsHY-L059
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Anti-Cancer Metabolism Compound Library3,849 compoundsHY-L083
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Cytokine Inhibitors Library1,438 compoundsHY-L161
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Mitophagy Compound Library660 compoundsHY-L180
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Epigenetics Compound Library Mini295 compoundsHY-L005M
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Lactic Acid Metabolite Compound Library59 compoundsHY-L250
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Ion Channel Compound Library1,764 compoundsHY-L166
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Dopamine Receptor Compound Library281 compoundsHY-L165
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Energy Metabolites Library89 compoundsHY-L263
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Serine/Threonine Kinase Inhibitor Library2,311 compoundsHY-L164
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High-Efficiency Gene Editing Compound Library767 compoundsHY-L244
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Extracellular Vesicles (EVs) Compound Library715 compoundsHY-L168
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Cell Death Inhibitor Library Mini23 compoundsHY-L162M
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RNA Binding Bioactive Compound Library858 compoundsHY-L248
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Metabolic Enzyme Compound Library4,443 compoundsHY-L146
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Cell Proliferation Compound Library3,685 compoundsHY-L201
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Lactylation Compound Library6,247 compoundsHY-L249
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Mitochondrial Protection Compound Library1,125 compoundsHY-L144
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Mitochondrial Toxicity Compound Library543 compoundsHY-L155
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Protease Inhibitor Library968 compoundsHY-L147
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KRAS Targeted Compound Library82 compoundsHY-L260
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Kinase Inhibitor Library Mini271 compoundsHY-L009M
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Cyclic Peptide Library100 compoundsHY-L110
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Peptide Library2,678 compoundsHY-L105
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Nucleotide Compound Library592 compoundsHY-L044
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Lipid Compound Library2,071 compoundsHY-L043
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Glycoside Compound Library919 compoundsHY-L042
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Heterocyclic Compound Library6,552 compoundsHY-L138
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Macrocyclic Compound Library473 compoundsHY-L041
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Covalent Screening Library Plus6,151 compoundsHY-L036P
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Covalent Screening Library1,624 compoundsHY-L036
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Peptidomimetic Library371 compoundsHY-L033
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Cysteine Targeted Covalent Library5,324 compoundsHY-L153
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Boronic Acid Compound Library166 compoundsHY-L167
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Peptide Compound Library877 compoundsHY-L105S
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Fatty Acids Compound Library427 compoundsHY-L182
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Dipeptide Compound Library73 compoundsHY-L255
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Ionizable Lipid Compound Library91 compoundsHY-L251
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Cysteine Targeted Covalent Fragment Library3,783 compoundsHY-L154
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PROTAC Library555 compoundsHY-L151
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Molecular Glue Compound Library126 compoundsHY-L137
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Tumorigenesis-Related Compound Library147 compoundsHY-L100
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Drug Metabolite Library450 compoundsHY-L098
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Animal Disease Model Inducer Library52 compoundsHY-L097
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Inactive Ingredient Library178 compoundsHY-L096
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Chemical Probe Library282 compoundsHY-L063
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Orally Active Compound Library5,581 compoundsHY-L061
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CNS-Penetrant Compound Library1,199 compoundsHY-L028
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Toxins for Antibody-Drug Conjugate Research Library115 compoundsHY-L023
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Food-Sourced Compound Library2,062 compoundsHY-L094
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Food Additive Library450 compoundsHY-L093
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Drug-Induced Liver Injury (DILI) Compound Library642 compoundsHY-L076
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Target Protein Ligand Library130 compoundsHY-L129
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E3 Ligase Ligand Library184 compoundsHY-L128
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Antibiotics Library750 compoundsHY-L067
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Neuroprotective Compound Library1,870 compoundsHY-L070
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Non-steroidal Anti-Inflammatory Compound Library635 compoundsHY-L130
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Macrophage Related Compound Library286 compoundsHY-L174
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Immunopotentiator Compound Library152 compoundsHY-L172
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Radiosensitizer Library40 compoundsHY-L179
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Alkyne Compound Library443 compoundsHY-L258
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Flavors and Fragrances Compound Library496 compoundsHY-L242
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Cancer Stem Cells Compound Library3,582 compoundsHY-L135
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Antibody Inhibitor Library1,973 compoundsHY-L177
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Highly Selective Inhibitors Library6,361 compoundsHY-L158
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Inflammasomes related Compound Library179 compoundsHY-L175
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Anti-Drug-Resistant Compound Library722 compoundsHY-L169
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Azide Compound Library100 compoundsHY-L256
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Radioprotector Library3,112 compoundsHY-L178
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Neurotransmitter Compound Library54 compoundsHY-L186
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Steroid Hormones Library69 compoundsHY-L239
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Cell Death Library3,890 compoundsHY-L162
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Chinese Baijiu Compound Library678 compoundsHY-L241
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Mitochondrial Toxicity Compound Library543 compoundsHY-L155
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Environmental Pollutant Compound Library294 compoundsHY-L247
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Pesticide Compound Library535 compoundsHY-L183
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Allosteric Modulators (AMs) Compound Library261 compoundsHY-L170
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Plant Hormone Library45 compoundsHY-L240