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Cat. No.: HY-142972

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19(S)-HETE

Name: 19(S)-HETE
Brand: MedChemExpress
SKU: HY-142972
Price: 475.00 USD
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19(S)-HETE is an arachidonic acid metabolite produced by cytochrome P450 enzymes. 19(S)-HETE is a full orthosteric agonist of the prostacyclin (IP) receptor with an EC₅₀ value of 567 nM. 19(S)-HETE inhibits platelet activation and relaxation of vessels.

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CAS No.: 115461-40-0
Formule: C₂₀H₃₂O₃
Masse moléculaire:320.47

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (260 KB)

19(S)-HETE Chemical Structure

CAS No.: 115461-40-0

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Activité biologique
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Prostaglandin Receptor :

In Vitro

19(S)-HETE (1 μM; 15 min) dose-dependently induces cAMP in MEG-01 cells with an EC₅₀ value of 520 nM^[1].
19(S)-HETE (1 μM-1 M) dose-dependently activates the IP receptor with an EC₅₀ value of 567 nM^[1].
19(S)-HETE (10 μM-1 M) displaces ³H-iloprost of IP receptor expressed COS-1 cells with a K_i value of 660 nM^[1].
19(S)-HETE (3 μM) relaxes arterial blood vessels and inhibits platelet activation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 115461-40-0
Masse moléculaire 320.47
Formule C₂₀H₃₂O₃
SMILES

C[C@H](O)CCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (260 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Tunaru S, et al. Arachidonic Acid Metabolite 19(S)-HETE Induces Vasorelaxation and Platelet Inhibition by Activating Prostacyclin (IP) Receptor. PLoS One. 2016 Sep 23;11(9):e0163633. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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