8-Pcpt-cGMP
Based on 1 publication(s) in Google Scholar
8-Pcpt-cGMP is an agonist for cyclic nucleotide-gated (CNG) channel with an EC50 of 0.5 μM. 8-Pcpt-cGMP exhibits good membrane permeability. 8-Pcpt-cGMP can be used in studies about the function of CNG channels in visual signal transduction and olfactory transduction.
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- CAS No.: 54364-02-2
- Formule: C16H15ClN5O7PS
- Masse moléculaire:487.81
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) 8-Pcpt-cGMP
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Activité biologique
Description
Chemical Information
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CAS No. 54364-02-2
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Masse moléculaire 487.81
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Formule C16H15ClN5O7PS
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SMILES
O[C@H]1[C@](O[C@@](CO2)([H])[C@@]1([H])O[P]2(O)=O)([H])N3C(NC(N)=NC4=O)=C4N=C3SC(C=C5)=CC=C5Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Sci Rep
2025 Oct 16;15(1):36270. PMID: 41102391
Protocole
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Transepithelial/transendothelial electrical resistance assay
TEER measures electrical resistance across epithelial or endothelial monolayers cultured on permeable supports, and the readout reflects ionic conductance through the cell barrier, especially the paracellular pathway regulated by junctional integrity. TEER can be measured without destroying the monolayer and is commonly used before or during transport, permeability, barrier-disruption, and barrier-maturation experiments. TEER values are influenced by biological maturation and technical conditions; reported factors include temperature, medium formulation, passage number, electrode geometry, membrane properties, and junctional length during early monolayer maturation. Therefore, TEER should be interpreted with blank-insert subtraction, area normalization, repeated readings, and, when possible, orthogonal barrier readouts such as FITC-dextran flux or tight-junction staining.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
8-Pcpt-cGMP Related Classifications
HY-137016 Related Classifications
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