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Cat. No.: HY-13320

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2-Keto Crizotinib

Name: 2-Keto Crizotinib
Brand: MedChemExpress
SKU: HY-13320
Price: 668.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: PF-06260182)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

2-Keto Crizotinib (PF-06260182) is an active lactam metabolite of crizotinib.

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CAS No.: 1415558-82-5
Formule: C₂₁H₂₀Cl₂FN₅O₂
Masse moléculaire:464.32

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

2-Keto Crizotinib Chemical Structure

CAS No.: 1415558-82-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Publications (1)
Pureté et documentation
Références
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Activité biologique

Description

2-Keto Crizotinib (PF-06260182) is an active lactam metabolite of crizotinib.

In Vitro

2-Keto Crizotinib (PF-06260182) is active and considerably less potent than crizotinib, and it is not thought to contribute significantly to the in vivo activity of crizotinib.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1415558-82-5
Masse moléculaire 464.32
Formule C₂₁H₂₀Cl₂FN₅O₂
SMILES

O=C1CC(N2N=CC(C3=CC(O[C@H](C)C4=C(Cl)C(F)=CC=C4Cl)=C(N)N=C3)=C2)CCN1
Synonyms

PF-06260182
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Gene

Selenoprotein S regulates tumorigenesis of clear cell renal cell carcinoma through AKT/ GSK3β/NF-κB signaling pathway. [Abstract]

2022 Jul 20;832:146559. PMID: 35569765

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Balis FM, e al. First-dose and steady-state pharmacokinetics of orally administered crizotinib in children with solid tumors: a report on ADVL0912 from the Children's Oncology Group Phase 1/Pilot Consortium. Cancer Chemother Pharmacol. 2017 Jan;79(1):181- [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

2-Keto Crizotinib

1 Cited Publications

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Activité biologique
- Description
- In Vitro
Chemical Information
Publications (1)
Pureté et documentation
Références

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2-Keto Crizotinib

Publications Citing Use of MedChemExpress (MCE) 2-Keto Crizotinib