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Cat. No.: HY-189133

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ARN24092

ARN24092 is a selective NKCC1 inhibitor. ARN24092 can be used for research on Down syndrome.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2746327-43-3
Formule: C₁₇H₂₅F₃N₂O₅S
Masse moléculaire:426.45

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ARN24092 Chemical Structure

CAS No.: 2746327-43-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Activité biologique

Description

ARN24092 is a selective NKCC1 inhibitor. ARN24092 can be used for research on Down syndrome^[1].

IC₅₀ & Target

^[1]

NKCC1

In Vitro

ARN24092 (compound 40) (10-100 μM; 15 min) significantly inhibits NKCC1 in cultured hippocampal neurons, with an inhibition rate of 13.9% at 10 μM and 51.9% at 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ARN24092 (compound 40) (0.6 mg/kg; intraperitoneal injection; daily; approximately 21 days) improved cognitive impairment across four different behavioral tasks in the Ts65Dn mouse model of Down syndrome without producing any diuretic effect^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Ts65Dn (C57BL/6JEi × C3H/HeSnJ F1 background, adult males, 2-4 months old for diuresis; 8-16 weeks old for behavioral testing)^[1]
Dosage:

0.6 mg/kg
Administration:

i.p.; daily; ~21 days
Result:

Did not induce significant diuresis in WT or Ts65Dn mice.
Fully restored short-term working memory in Ts65Dn mice in T-maze.
Completely rescued poor novel-discrimination ability in Ts65Dn mice in NOR task.
Completely restored associative memory in Ts65Dn mice in CFC test.
Rescued hyperactivity in Ts65Dn mice in open-field test.
Did not affect general health or body weight after 3 weeks of daily administration.

Chemical Information

CAS No. 2746327-43-3
Masse moléculaire 426.45
Formule C₁₇H₂₅F₃N₂O₅S
SMILES

O=C(C1=C(O)C=C(NCCCCCCCC(F)(F)F)C(S(=O)(N(C)C)=O)=C1)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Borgogno M, et al. Design, Synthesis, In Vitro and In Vivo Characterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in Down Syndrome. J Med Chem. 2021 Jul 22;64(14):10203-10229.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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