Atiprosine
Atiprosine (AY-28228) is an orally effective selective α1-adrenergic receptor antagonist with a pA2 value of 8.11. Atiprosine exhibits antagonistic activity against α2-adrenergic receptors (α1-adrenergic receptor), 5-HT₂ receptors (5-HT₂ receptor), and H₁ receptors (H₁ receptor). The pA2 values for these receptors are 6.04, 6.87, and 7.32 respectively. Atiprosine has antihypertensive and hypotensive effects in rats, dogs, and monkeys. It can be used for research on cardiovascular and mental disorders.
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- CAS No.: 89303-63-9
- Formule: C20H29N3
- Masse moléculaire:311.46
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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α1-adrenergic receptor 8.11 (pA2) |
α2-adrenergic receptor 6.04 (pA2) |
5-HT2 Receptor 6.87 (pA2) |
H1 Receptor 7.32 (pA2) |
Chemical Information
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CAS No. 89303-63-9
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Masse moléculaire 311.46
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Formule C20H29N3
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SMILES
CC(C)N1CCN([C@@]2([C@@]1(CCN3C2=C(C4=C3C=CC=C4)C)[H])[H])CC
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Synonyms
AY-28228
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Oshiro G, et al. Antihypertensive and hypotensive actions of atiprosin (AY-28,228) in rats, dogs, and monkeys. J Cardiovasc Pharmacol. 1987 Sep;10(3):341-9. [Content Brief]
[2]. Grimes D, et al. In vitro isolated tissue studies with atiprosin (AY-28,228): a new antihypertensive compound. J Cardiovasc Pharmacol. 1987 Sep;10(3):249-58. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Atiprosine Related Classifications
HY-119854 Related Classifications
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