cis-Lomibuvir
cis-Lomibuvir (cis-VX-222) is the cis-isomer of Lomibuvir. Lomibuvir (VX-222), a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis. cis-Lomibuvir is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 1026785-59-0
- Formule: C25H35NO4S
- Masse moléculaire:445.61
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
-
HY-10241
SimeprevirHCV NS3/4A Inhibitor -
HY-14434
AsunaprevirHCV Protease Inhibitor -
HY-10238
DanoprevirHCV NS3/4A Inhibitor -
HY-10544
Tegobuvir -
HY-10237
BoceprevirHCV NS3 Protease Inhibitor -
HY-10235
TelaprevirHCV NS3-4A Protease Inhibitor -
HY-15602
LedipasvirHCV NS5A Inhibitor -
HY-15236
PSI-6206HCV Inhibitor -
HY-15298
GrazoprevirHCV Protease Inhibitor -
HY-10465
Daclatasvir dihydrochlorideHCV NS5A Inhibitor -
HY-17634
GlecaprevirHCV NS3/4A Protease Inhibitor -
HY-10300
NarlaprevirNS3 Protease Inhibitor
Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis
More
Activité biologique
Description
Chemical Information
-
CAS No. 1026785-59-0
-
Masse moléculaire 445.61
-
Formule C25H35NO4S
-
SMILES
O=C(C1=C(N([C@H]2CC[C@@H](O)CC2)C([C@H]3CC[C@H](C)CC3)=O)C=C(C#CC(C)(C)C)S1)O
-
Synonyms
cis-VX-222
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Yi G, Deval J, et al. Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir. Antimicrob Agents Chemother. 2012;56(2):830-837. [Content Brief]
[2]. Li P, Dorsch W, et al. Discovery of Novel Allosteric HCV NS5B Inhibitors. 2. Lactam-Containing Thiophene Carboxylates. ACS Med Chem Lett. 2017;8(2):251-255. Published 2017 Jan 31. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
cis-Lomibuvir Related Classifications
HY-114571 Related Classifications
Powered by Bioz