Cat. No.: HY-147794

CDK9-IN-41

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CDK9-IN-41 is a potent CDK9, EGFR, HER2, and COX-2 kinases inhibitor with IC₅₀s of 192.81 nM, 254.03 nM, 238.81 nM, and 775 nM. COX-2-IN-18 exhibits remarkable antitumor activity against leukemia cancer cells, colon cancer cells, melanoma cells, ovarian cells and breast cells.

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Pureté: 98.84%
CAS No.: 1038061-96-9
Formule: C₁₈H₁₉N₃O₃S₂
Masse moléculaire:389.49

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

CDK9-IN-41 Chemical Structure

CAS No.: 1038061-96-9

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

CDK9

192.81 nM (IC₅₀)

HER2

238.81 nM (IC₅₀)

EGFR

254.03 nM (IC₅₀)

COX-2

775 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform CDK :

Voir tous les produits spécifiques à Isoform COX :

Voir tous les produits spécifiques à Isoform EGFR :

In Vitro

CDK9-IN-41 (Compound 3) has antitumor activity presented as growth inhibition percentages (GI%) for 59 subpanel tumor cell lines. Leukemia (CCRF-CEM, 20%; HL-60(TB), 30%; MOLT-4, 20%; RPMI-8226, 20%; SR, 19%), NSC Lung (A549/ATCC, 20%; HOP-92, 14%; NCI-H322M, 19%; NCI-H23, 12%; NCI-H522, 24%), Colon (HCT-116, 21%; HCT-15, 12%), CNS (SF-539, 12%; SNB-19, 12%; U251, 12%), Melanoma (LOX IMVI, 23%; MALME-3 M, 25%; SK-MEL-5, 11%; UACC-62, 24%), Ovarian (OVCAR-8, 12%; A-498, 12%; RXF-393, 13%; UO-31, 35%), Prostate (PC-3, 13%), Breast (MDA-MB-231/ATCC, 29%; HS-578 T, 18%; T-47D, 15%; MDA-MB-468, 12%)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1038061-96-9
Appearance Solid
Masse moléculaire 389.49
Formule C₁₈H₁₉N₃O₃S₂
Color White to off-white
SMILES

O=S(C1=CC=C(CCN2C(SCC)=NC3=C(C=CC=C3)C2=O)C=C1)(N)=O
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. El-Azab AS, et al. Antitumor activity, multitarget mechanisms, and molecular docking studies of quinazoline derivatives based on a benzenesulfonamide scaffold: Cell cycle analysis. Bioorg Chem. 2020;104:104345. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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CDK9-IN-41

Cell Cycle/DNA Damage Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Differentiation Inducing Compound Library

Pyroptosis Compound Library

Anti-Hepatitis C Virus Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Obesity Compound Library

Angiogenesis-Related Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Antidepressant Compound Library

Anti-Prostate Cancer Compound Library

Cancer Stem Cells Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cytokine Inhibitors Library

Serine/Threonine Kinase Inhibitor Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Anti-Gastric Cancer Compound Library

Anti-Brain Cancer Compound Library

Protein Kinase Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Anti-Rheumatic Arthritis Compound Library

High-Efficiency Gene Editing Compound Library

Voir tous les produits spécifiques à Isoform CDK

Voir tous les produits spécifiques à Isoform COX

Voir tous les produits spécifiques à Isoform EGFR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

CDK9-IN-41 Related Classifications

HY-147794 Related Classifications