DENV-IN-9
Based on 1 Customer Validation
DENV-IN-9 (Compound 5f) is a DENV2 inhibitor with an EC50 of 0.88 μM.
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- Pureté: 98.77%
- CAS No.: 791838-63-6
- Formule: C15H9BrO5
- Masse moléculaire:349.13
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
EC50: 0.88 μM (DENV2)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KB | IC50 |
14.1 μM
Compound: 25
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Inhibitory activity against KB cell line after 72 h of drug exposure
Inhibitory activity against KB cell line after 72 h of drug exposure
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[PMID: 15481991] |
| KB 3-1 | EC50 |
15 μM
Compound: 25
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Concentration that causes 50% of maximum vinblastine accumulation in KB/MDR cells in 1 h
Concentration that causes 50% of maximum vinblastine accumulation in KB/MDR cells in 1 h
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[PMID: 15481991] |
| KB 3-1 | IC50 |
18.7 μM
Compound: 25
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Inhibitory activity against KB/MDR cell line after 72 hr of drug exposure
Inhibitory activity against KB/MDR cell line after 72 hr of drug exposure
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[PMID: 15481991] |
DENV-IN-9 (Compound 5f) (72 h) shows anti-dengue activity with an EC50 of 0.88 ± 0.14 μM against DENV2-infected LLC/MK2 cells and exhibits low toxicity against normal cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 791838-63-6
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Appearance Solid
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Masse moléculaire 349.13
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Formule C15H9BrO5
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Color brownish yellow
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SMILES
O=C1C=C(C2=CC=CC=C2)OC3=C1C(O)=C(O)C(O)=C3Br
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
DMSO : 50 mg/mL (143.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8643 mL | 14.3213 mL | 28.6426 mL | 71.6066 mL |
| 5 mM | 0.5729 mL | 2.8643 mL | 5.7285 mL | 14.3213 mL | |
| 10 mM | 0.2864 mL | 1.4321 mL | 2.8643 mL | 7.1607 mL | |
| 15 mM | 0.1910 mL | 0.9548 mL | 1.9095 mL | 4.7738 mL | |
| 20 mM | 0.1432 mL | 0.7161 mL | 1.4321 mL | 3.5803 mL | |
| 25 mM | 0.1146 mL | 0.5729 mL | 1.1457 mL | 2.8643 mL | |
| 30 mM | 0.0955 mL | 0.4774 mL | 0.9548 mL | 2.3869 mL | |
| 40 mM | 0.0716 mL | 0.3580 mL | 0.7161 mL | 1.7902 mL | |
| 50 mM | 0.0573 mL | 0.2864 mL | 0.5729 mL | 1.4321 mL | |
| 60 mM | 0.0477 mL | 0.2387 mL | 0.4774 mL | 1.1934 mL | |
| 80 mM | 0.0358 mL | 0.1790 mL | 0.3580 mL | 0.8951 mL | |
| 100 mM | 0.0286 mL | 0.1432 mL | 0.2864 mL | 0.7161 mL |
DENV-IN-9 Related Classifications
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