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Cat. No.: HY-187745A

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DPPE-PEG2000-MTP

Name: DPPE-PEG2000-MTP
Brand: MedChemExpress
SKU: HY-187745A
Availability: PreOrder

(Synonyms: DPPE-PEG2000-Mal-Cys-ASSLNIA)

DPPE-PEG2000-MTP (DPPE-PEG2000-Mal-Cys-ASSLNIA) is a functionalized PEGylated phospholipid conjugate composed of three modular components: 1,2-dipalmitoyl-sn-glycerol-3-phosphate ethanolamine (DPPE) as a lipid anchoring group, a 2000 Da polyethylene glycol (PEG) spacer arm, and an MTP (HY-P10643) peptide as a terminal targeting/functional ligand. DPPE-PEG2000-MTP can be used in research on muscle-targeted drug delivery and muscle tissue gene delivery.

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Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DPPE-PEG2000-MTP Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

In Vitro

DPPE-PEG2000-MTP is composed of three covalently linked components: 1. DPPE (1,2-dipalmitoyl-sn-glycerol-3-phosphoethanolamine): Lipid anchoring group-inserts into the lipid bilayer of liposomes/LNPs, providing stable membrane anchoring; its saturated C16 chain imparts bilayer rigidity. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing steric separation between the lipid surface and the targeting ligand. 3. MTP peptide: Targeting/functional ligand-MTP peptide is a muscle-targeting peptide that mediates the targeted delivery of the carrier to muscle tissue, increasing drug accumulation in muscle tissue.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

SMILES

[DPPE-PEG2000-MTP]
Synonyms

DPPE-PEG2000-Mal-Cys-ASSLNIA
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Yu CY, et al. A muscle-targeting peptide displayed on AAV2 improves muscle tropism on systemic delivery. Gene Ther. 2009 Aug;16(8):953-62. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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