Eticlopride
Based on 1 publication(s) in Google Scholar
Eticlopride, a selective dopamine D2‐like receptor antagonist, exhibits high affinity for dopamine D2, α1‐adrenergic, α2‐adrenergic, 5HT1, 5HT2 receptors with Kis of 0.09, 112, 699, 6220, and 830 nM, respectively. Eticlopride is an antipsychotic agent.
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- CAS No.: 84226-12-0
- Formule: C17H25ClN2O3
- Masse moléculaire:340.85
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Stockage:
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) Eticlopride
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| HEK-293T | IC50 |
>10000 nM
Compound: Eticlopride
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Antagonist activity at DRD2 (unknown origin) expressed in HEK293T cells transfected with Galphai1-RLuc8 and gamma2-GFP10 assessed as inhibition of quinpirole-induced Gi1 activation pre-incubated with quinpirole for 10 mins before compound incubation for 1
Antagonist activity at DRD2 (unknown origin) expressed in HEK293T cells transfected with Galphai1-RLuc8 and gamma2-GFP10 assessed as inhibition of quinpirole-induced Gi1 activation pre-incubated with quinpirole for 10 mins before compound incubation for 1
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[PMID: 27933960] |
In Vitro
Eticlopride (1 μM, 6 h) abrogates the action of DA, where DA increases KLF2 expression in HUVEC cells[2].
Eticlopride (1 μM, 15 min) abolishes heterodimerization of D2R/SSTR2 in rat striatal neurons[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
Eticlopride (0.01 or 0.02 mg/kg, i.p.) alleviates cognitive deficits produced by Quinpirole (HY-B1752) in rats[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats treated with Ruinpirole (1 mg/kg) from postnatal days 1 to 21[4]
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Dosage:0.01 or 0.02 mg/kg
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Administration:i.p.
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Result:Alleviated cognitive deficits produced by neonatal quinpirole treatment in both male and female rats on the place version of the MWT, as well as in males tested on the match-to-place version of the MwT (MwT tested on P22 to P28).
Chemical Information
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CAS No. 84226-12-0
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Masse moléculaire 340.85
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Formule C17H25ClN2O3
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SMILES
O=C(C1=C(C(CC)=CC(Cl)=C1OC)O)NC[C@H]2N(CCC2)CC
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Synonyms
FLB-131
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Glia
Sustained Neuronal Stimulation Activates Paraventricular Thalamus Astrocytes for Chronicity of Neuropathic Pain in Mice. [Abstract]2026 Aug;74(8):e70183. PMID: 42231639
Pureté et documentation
Références
[2]. Chakroborty D, et al. Dopamine stabilizes tumor blood vessels by up-regulating angiopoietin 1 expression in pericytes and Kruppel-like factor-2 expression in tumor endothelial cells. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20730-5. [Content Brief]
[3]. Baragli A, et al. Heterooligomerization of human dopamine receptor 2 and somatostatin receptor 2 Co-immunoprecipitation and fluorescence resonance energy transfer analysis. Cell Signal. 2007 Nov;19(11):2304-16. [Content Brief]
[4]. Brown RW, et al. The effects of eticlopride on Morris water task performance in male and female rats neonatally treated with quinpirole. Psychopharmacology (Berl). 2005 Jul;180(2):234-40. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Eticlopride Related Classifications
HY-121129 Related Classifications
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