SPIN4 - spindlin family member 4 Gene

Also Known as TDRD28

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 139886

About SPIN4

This gene has 1 transcript (splice variant), 230 orthologues and 4 paralogues.

Summary

Enables methylated histone binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be active in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SPIN4 Products (1)

mRNA Protein Name
NM_001012968.3 NP_001012986.2 spindlin-4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables methylated histone binding IDA
IDA: Inferred from direct assay
29061846 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
29061846 GOA
Biological Process GO Annotation Evidence Références Source
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
36927955 GOA
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
36927955 GOA
Cellular Component GO Annotation Evidence Références Source
located in chromatin IDA
IDA: Inferred from direct assay
36927955 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
36927955 GOA
located in nucleus IDA
IDA: Inferred from direct assay
36927955 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPIN4 Protein Structure

Spin-Ssty

Spin-Ssty: Spin/Ssty Family (41 - 90)

Spin-Ssty

Spin-Ssty: Spin/Ssty Family (119 - 168)

Spin-Ssty

Spin-Ssty: Spin/Ssty Family (201 - 246)

  • 0
  • 100
  • 200
  • 249 a.a.
Protein Preferred Names Protein Names

spindlin-4

Related Diseases

Diseases Alias
Hyperekplexia

  • Hereditary Hyperekplexia

  • Kok Disease

  • Congenital Stiff Man Syndrome

  • Familial Startle Disease

  • Sthe

  • Stiff-Baby Syndrome

  • Hereditary Hyperexplexia

  • Startle Disease

  • Exaggerated Startle Reaction

  • Hyperexplexia Hereditary

  • Startle Disease, Familial

  • Startle Reaction, Exaggerated

  • Stiff-Man Syndrome, Congenital

  • Stiff-Person Syndrome, Congenital

  • Congenital Stiff-Man Syndrome

  • Congenital Stiff-Person Syndrome

  • Familial Hyperekplexia

  • Startle Syndrome

  • Stiff Baby Syndrome

  • Hyperekplexia, Hereditary

  • Stiff-Person Syndrome
Patent Foramen Ovale

  • Atrial Septal Defect Within Oval Fossa

  • Foramen Ovale Patent

  • Ostium Secundum Atrial Septal Defect

  • Atrial Septal Defect, Ostium Secundum Type

  • Foramen Ovale, Patent

  • Defect, Patent Or Persistent, Ostium Secundum

  • Ostium Secundum Type Atrial Septal Defect

  • Persistent Ostium Secundum

  • Asd Ostium Secundum Type

  • Ostium Secundum Asd

  • Osasd

  • Asd, Ostium Secundum Type

  • Pfo - [Patent Foramen Ovale]

  • Open Foramen Ovale

  • Open Oval Foramen

  • Persistent Foramen Ovale

  • Secundum Atrial Septal Defect
Early Infantile Epileptic Encephalopathy

  • Early Infantile Epileptic Encephalopathy With Burst-Suppression

  • Early Infantile Epileptic Encephalopathy With Suppression Bursts

  • Eiee

  • Early Infantile Epileptic Encephalopathy With Suppression-Bursts

  • Ohtahara Syndrome

  • Encephalopathy, Epileptic, Early Infantile
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS13677 SPIN4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22826 Spin4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24403 Serpine2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29341 Spin4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SPIN4 VGNC VGNC:78004
Mus musculus SPIN4 MGD MGI:2444925
Bos taurus SPIN4 VGNC VGNC:35218
Rattus norvegicus SPIN4 RGD RGD:1564004
Felis catus SPIN4 VGNC VGNC:65638
Canis familiaris SPIN4 VGNC VGNC:46743
Others SPIN4 NCBI