NKX6-1 - NK6 homeobox 1 Gene

Also Known as NKX6A; NKX6.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4825

About NKX6-1

Cytogenetic location: 4q21.23 Genomic coordinates (GRCh38): 4:84,491,985-84,499,292 (from NCBI)

This gene has 2 transcripts (splice variants), 202 orthologues and 13 paralogues. Biased expression in esophagus (RPKM 3.3), thyroid (RPKM 0.9) and 4 other tissues.

Summary

In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].[supplied by OMIM, Mar 2008]

NKX6-1 Products (1)

mRNA Protein Name
NM_006168.3 NP_006159.2 homeobox protein Nkx-6.1

NKX6-1 Protein Structure

Homeobox

Homeobox: Homeobox domain (237 - 293)

  • 0
  • 100
  • 200
  • 300
  • 367 a.a.
Protein Preferred Names Protein Names

homeobox protein Nkx-6.1

  • NK homeo box, family 6, member A

NKX6-1 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P81474 NKX6.1 Antibody (YA1219) IHC-P Human
HY-P81474A NKX6.1 Antibody (YA1219)(PBS only) IHC-P Human

Related Diseases

Diseases Alias
Pancreatic Agenesis

  • Partial Pancreatic Agenesis

  • Congenital Pancreatic Agenesis

  • Partial Agenesis Of The Pancreas

  • Agenesis, Pancreatic

  • Pancreatic Agenesis, Congenital
Maturity-Onset Diabetes Of The Young, Type 4

  • Maturity-Onset Diabetes Of The Young Type 4

  • MODY4

  • Mody, Type Iv

  • Mody Type 4

  • Mody, Type 4

  • Maturity-Onset Diabetes Of The Young 4

  • Mody-4

  • Diabetes Of The Young, Maturity-Onset, Type 4

  • Maturity-Onset Diabetes Of The Young, Type Iv
Neonatal Diabetes

  • Neonatal Diabetes Mellitus

  • Diabetes Mellitus Syndrome In Newborn Infant

  • Ndm
Maturity-Onset Diabetes Of The Young, Type 3

  • Maturity-Onset Diabetes Of The Young Type 3

  • MODY3

  • Mody, Type Iii

  • Mody Type 3

  • Mody, Type 3

  • Maturity-Onset Diabetes Of The Young 3

  • Mody-3

  • Diabetes Of The Young, Maturity-Onset, Type 3
Maturity-Onset Diabetes Of The Young

  • MODY

  • Maturity Onset Diabetes Mellitus In Young

  • Mason-Type Diabetes

  • Mason Type Diabetes

  • Maturity Onset Diabetes Of The Young

  • Mody Syndrome

  • Diabetes Of The Young, Maturity-Onset
Permanent Neonatal Diabetes Mellitus

  • Pndm

  • Permanent Diabetes Mellitus Of Infancy

  • Pdmi

  • Neonatal Diabetes Mellitus, Permanent
Maturity-Onset Diabetes Of The Young, Type 1

  • Maturity-Onset Diabetes Of The Young Type 1

  • MODY1

  • Mild Juvenile Diabetes Mellitus

  • Mody, Type I

  • Diabetes Mellitus Type 2

  • Mody Type 1

  • Mody, Type 1

  • Maturity-Onset Diabetes Of The Young 1

  • Mody-1

  • Diabetes Of The Young, Maturity-Onset, Type 1
Pancreatic Cystadenoma

  • Cystadenoma Of Pancreas
Diabetes Mellitus

  • Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS09335 NKX6-1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NKX6-1 VGNC VGNC:78535
Rattus norvegicus NKX6-1 RGD RGD:69318
Bos taurus NKX6-1 VGNC VGNC:32107
Canis familiaris NKX6-1 VGNC VGNC:54334
Macaca mulatta NKX6-1 VGNC VGNC:75356
Mus musculus NKX6-1 MGD MGI:1206039
Others NKX6-1 NCBI