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Cat. No.: HY-P12384

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GPQ-W

GPQ-W is a synthetic peptide containing a type I collagen-derived protease cleavage site and serves as a protease-degradable crosslinker in PEG-4MAL/RGD synthetic hydrogels. GPQ-W is cleaved by cell-secreted matrix metalloproteinases, enabling cell-mediated matrix degradation and remodeling. GPQ-W, as a PEG-4MAL hydrogel component, supports the in vitro generation of human intestinal and lung organoids from hPSC-derived spheroids, long-term survival of intestinal organoids, normal epithelial cyst polarity, and lumen formation at the rapidly degrading crosslinker threshold level. GPQ-W can be used in research related to intestinal mucosal injury and organoid transplantation.

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CAS No.: 287184-75-2
Formule: C₆₈H₁₀₅N₂₅O₂₃S₂
Masse moléculaire:1704.85

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Please store the product under the recommended conditions in the Certificate of Analysis.

GPQ-W Chemical Structure

CAS No.: 287184-75-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

In Vitro

GPQ-W (15.57 mM; incubated at 37 °C for 20 min) is prepared into a crosslinker solution, which can be used to form PEG-4MAL hydrogels^[1].
GPQ-W-crosslinked PEG-4MAL hydrogels support the in vitro generation of HIOs from hPSC-derived intestinal spheroids, form lumens within 4-5 d, and can maintain HIOs for up to approximately 21 d with passaging for three generations^[1].
GPQ-W cross-linked 3D FRC cultures enhance human tonsillar B/T cell survival and antigen-specific B cell responses, and promote GC/ASC differentiation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 287184-75-2
Masse moléculaire 1704.85
Formule C₆₈H₁₀₅N₂₅O₂₃S₂
SMILES

O=C(N[C@@H](CS)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(NCC(N1[C@@H](CCC1)C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CS)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN
Sequence

Gly-Cys-Arg-Asp-Gly-Pro-Gln-Gly-Ile-Trp-Gly-Gln-Asp-Arg-Cys-Gly
Sequence Shortening

GCRDGPQGIWGQDRCG
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Cruz-Acuña R, et al. PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery. Nat Protoc. 2018 Sep;13(9):2102-2119. doi: 10.1038/s41596-018-0036-3. Erratum in: Nat Protoc. 2019 Jul;14(7):2258. [Content Brief]

[2]. Braham MVJ, et al. Enhanced Human Antigen-Specific B Cell Responses Using In Vitro 3D Tonsil Cultures Containing Stromal Cells. Advanced healthcare materials. 2026 Jun;15(22):e04886.

Calculators

Calculateur de molarité

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Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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