LY-289612
LY-289612 is a HIV-1 protease inhibitor, with an IC50 of 1.5 nM.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 148314-61-8
- Formule: C35H39N5O5
- Masse moléculaire:609.71
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
IC50 & Target
IC50: 1.5 nM (HIV-1 protease)[1]
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | ED50 |
23 nM
Compound: 1
|
Concentration required for inhibitory activity against CEM cells in a whole cell assay.
Concentration required for inhibitory activity against CEM cells in a whole cell assay.
|
10.1016/0960-894X(95)00101-X |
| CCRF-CEM | IC50 |
13.67 ng/mL
Compound: LY-289612
|
Compound was tested for whole cell antiviral activity against CEM cell lines
Compound was tested for whole cell antiviral activity against CEM cell lines
|
10.1016/S0960-894X(01)80186-4 |
| CCRF-CEM | IC50 |
23 nM
Compound: LY-289612
|
Concentration required for antiviral activity using infected CEM cells
Concentration required for antiviral activity using infected CEM cells
|
10.1016/S0960-894X(01)80367-X |
| CCRF-CEM | IC50 |
23 nM
Compound: LY-289612
|
Concentration required for in vitro antiviral activity against HIV-1 virus infected CEM cells
Concentration required for in vitro antiviral activity against HIV-1 virus infected CEM cells
|
10.1016/S0960-894X(01)80368-1 |
| CCRF-CEM | IC50 |
27 nM
Compound: 1
|
Antiviral activity in HIV-infected CEM cells using whole cell assay
Antiviral activity in HIV-infected CEM cells using whole cell assay
|
10.1016/0960-894X(95)00102-Y |
| MT2 | IC50 |
31.7 ng/mL
Compound: LY-289612
|
Compound was tested for whole cell antiviral activity against MT2 cell lines
Compound was tested for whole cell antiviral activity against MT2 cell lines
|
10.1016/S0960-894X(01)80186-4 |
| MT2 | IC50 |
52 nM
Compound: LY-289612
|
Concentration required for in vitro antiviral activity against HIV-1 virus infected MT2 cells
Concentration required for in vitro antiviral activity against HIV-1 virus infected MT2 cells
|
10.1016/S0960-894X(01)80368-1 |
Chemical Information
-
CAS No. 148314-61-8
-
Masse moléculaire 609.71
-
Formule C35H39N5O5
-
SMILES
O=C(N[C@@H](CC1=CC=CC=C1)[C@H](O)CC2=CC=CC=C2C(NC(C)(C)C)=O)[C@@H](NC(C3=NC4=CC=CC=C4C=C3)=O)CC(N)=O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LY-289612 Related Classifications
HY-135459 Related Classifications
Powered by Bioz