PDE4B-IN-7
PDE4B-IN-7 is a PDE-4B inhibitor with an IC50 of 160 nM. PDE4B-IN-7 can form a firm and stable binding with the active site of PDE-4B. PDE4B-IN-7 inhibits acetylcholine-induced bronchospasm in guinea pigs. PDE4B-IN-7 exerts activity against susceptible Gram-positive and Gram-negative bacterial strains. PDE4B-IN-7 can be used for the researches of asthma and bacterial agent.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 1226697-79-5
- Formule: C15H14BrN5O3S
- Masse moléculaire:424.27
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
|
PDE4B 160 nM (IC50) |
PDE4B-IN-7 (Compound 17k) (1-1000 ng/mL; 20 min) potently inhibits human recombined PDE-4B in vitro with an IC50 of 160 nM[1].
PDE4B-IN-7 (31.15-500 μg/mL; 18-24 h) shows potent in vitro antibacterial activity against S. aureus (MIC = 0.07 μg/mL) and significant activity against E. coli (MIC = 8.074 μg/mL)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:S. aureus and E. coli
-
Concentration:31.15–500 μg/mL
-
Incubation Time:18-24 h
-
Result:Showed a MIC of 0.07 μg/mL for S. aureus and MIC of 8.074 μg/mL for E. coli.
PDE4B-IN-7 (i.p.) has an LD50 of 300 mg/kg via intraperitoneal injection in male albino mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Hartley (male, 300-400 g, bronchospasm induced by acetylcholine injection)[1]
-
Dosage:2.5 mg/kg; 5 mg/kg; 10 mg/kg
-
Administration:i.p.
-
Result:Reduced acetylcholine-induced bronchospasm by 25.1% at 2.5 mg/kg.
Reduced acetylcholine-induced bronchospasm by 47.9% at 5 mg/kg.
Reduced acetylcholine-induced bronchospasm by 78.3% at 10 mg/kg.
Achieved an IC50 value of 5.8 mg/kg.
Chemical Information
-
CAS No. 1226697-79-5
-
Masse moléculaire 424.27
-
Formule C15H14BrN5O3S
-
SMILES
O=C1C2=C(N=C(SCC(NC3=CC=C(Br)C=C3)=O)N2)N(C)C(N1C)=O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PDE4B-IN-7 Related Classifications
HY-181770 Related Classifications
Powered by Bioz