1000690-91-4
1000690-91-4
Chemical Structure
Cetirizine Impurity B dihydrochloride
- CAS No.: 1000690-91-4
- Formula:C19H23Cl3N2O2
- Molecular Weight:417.76
IUPAC Name: 2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)acetic acid dihydrochloride
InChIKey: LSPZEDLYSAUAQV-UHFFFAOYSA-N
SMILES: O=C(O)CN1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1.[H]Cl.[H]Cl
Biological Activity: Cetirizine Impurity B dihydrochloride is an impurity of Cetirizine dihydrochloride. Cetirizine, a second-generation antihistamine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].
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Cetirizine Impurity B dihydrochloride | Cetirizine Impurity B dihydrochloride is an impurity of Cetirizine dihydrochloride. Cetirizine, a second-generation antihistamine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response. | |||||||||||||||||||||
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References
- [1]. Caroline M. Spencer, et al. Cetirizine. Drugs 46 (6): 1055-1080, 1993.
- [2]. Shih MY, et al. Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. Allergy Asthma Proc. 2008 Sep-Oct;29(5):480-5. [Content Brief]
- [3]. Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34(1):103-9. [Content Brief]
