1000852-57-2
1000852-57-2
Chemical Structure
Eoxin E4
Synonym(s): 14,15-LTE4; EoxE4
- CAS No.: 1000852-57-2
- Formula:C23H37NO5S
- Molecular Weight:439.61
IUPAC Name: (5Z,8Z,10E,12E,14R,15S)-14-(((R)-2-amino-2-carboxyethyl)thio)-15-hydroxyicosa-5,8,10,12-tetraenoic acid
InChIKey: JLJNENVYAVKECZ-HRXVJLLUSA-N
SMILES: CCCCC[C@@H]([C@@H](/C=C/C=C/C=C\C/C=C\CCCC(O)=O)SC[C@@H](C(O)=O)N)O
Biological Activity: Eoxin E4 (14,15-LTE4) is the metabolite of 14,15-LTC4 and 14,15-LTD4. Eoxin E4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency than LTC4, but approximately 100-fold greater potency than histamine[1][2].
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Eoxin E4 | Eoxin E4 (14,15-LTE4) is the metabolite of 14,15-LTC4 and 14,15-LTD4. Eoxin E4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency than LTC4, but approximately 100-fold greater potency than histamine. | |||||||||||||||||||||
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References
- [1]. Bryant RW, et al. Leukotriene formation by a purified reticulocyte lipoxygenase enzyme. Conversion of arachidonic acid and 15-hydroperoxyeicosatetraenoic acid to 14, 15-leukotriene A4. J Biol Chem. 1985 Mar 25;260(6):3548-55. [Content Brief]
- [2]. Luo M, et al. Leukotriene synthesis by epithelial cells. Histol Histopathol. 2003 Apr;18(2):587-95. [Content Brief]
