1009373-58-3
1009373-58-3
Chemical Structure
11β-HSD1-IN-24
- CAS No.: 1009373-58-3
- Formula:C26H33BrN2O3
- Molecular Weight:501.46
InChIKey: GWEYXGKHUJIVFK-UHFFFAOYSA-N
SMILES: O=C(CC1C2=C(C3(C1)CCN(CC3)C(NC4C5CC6CC(CC4C6)C5)=O)C(Br)=CC=C2)O
Biological Activity: 11β-HSD1-IN-24 (Compound 10l) is a potent and selective 11β-HSD1 inhibitor with an IC50 of 0.5 nM. 11β-HSD1-IN-24 can effectively block the conversion of inactive Cortisone (HY-17461) to active Cortisol (HY-N0583). 11β-HSD1-IN-24 can be used for the research of metabolic disease, such as type 2 diabetes[1].
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11β-HSD1-IN-24 | 11β-HSD1-IN-24 (Compound 10l) is a potent and selective 11β-HSD1 inhibitor with an IC50 of 0.5 nM. 11β-HSD1-IN-24 can effectively block the conversion of inactive Cortisone (HY-17461) to active Cortisol (HY-N0583). 11β-HSD1-IN-24 can be used for the research of metabolic disease, such as type 2 diabetes. | |||||||||||||||||||||
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References
Keywords
