1009583-83-8
1009583-83-8
Chemical Structure
(R)-BMS-816336
- CAS No.: 1009583-83-8
- Formula:C21H27NO3
- Molecular Weight:341.44
IUPAC Name: 2-((1R,2R,3S,5R,6R,7S)-6-hydroxy-2-phenyladamantan-2-yl)-1-(3-hydroxyazetidin-1-yl)ethan-1-one
InChIKey: OAAZMUGLOXGVNH-SCTVKTQDSA-N
SMILES: O[C@H]1[C@H]2C[C@@H]3[C@@](C4=CC=CC=C4)(CC(N5CC(O)C5)=O)[C@@H](C[C@H]1C3)C2
Biological Activity: (R)-BMS-816336 (Compound 6n-1) is a potent and orally active inhibitor of human, mouse and cynomolgus monkey 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with IC50s of 14.5 nM, 50.3 nM and 16 nM, respectively [1].
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(R)-BMS-816336 | (R)-BMS-816336 (Compound 6n-1) is a potent and orally active inhibitor of human, mouse and cynomolgus monkey 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with IC50s of 14.5 nM, 50.3 nM and 16 nM, respectively . | |||||||||||||||||||||
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