1011528-65-6
Chemical Structure
Phanginin H
- CAS No.: 1011528-65-6
- Formula:C21H28O4
- Molecular Weight:344.44
InChIKey: QWUTUYGUGLFBMY-UQOSMDEQSA-N
SMILES: COC([C@]1([C@@]2([H])[C@]3(CCC1)[C@@]4([H])[C@@](C5=C(C=CO5)[C@@H]([C@]4([H])CC2)C)([H])OC3)C)=O
Biological Activity: Phanginin H is an Autophagy inducer with an IC50 of 18.13 μM in PANC-1 cells. Phanginin H induces Reactive Oxygen Species accumulation and mitochondrial depolarization, activates AMPK signaling, inhibits mTORC1/ULK signaling and promotes autophagic flux, and simultaneously induces G2/M phase cell cycle arrest, thereby inhibiting PANC-1 cell proliferation, spheroid formation, and migration. Phanginin H can be used in research related to pancreatic ductal adenocarcinoma[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Phanginin H | Phanginin H is an Autophagy inducer with an IC50 of 18.13 μM in PANC-1 cells. Phanginin H induces Reactive Oxygen Species accumulation and mitochondrial depolarization, activates AMPK signaling, inhibits mTORC1/ULK signaling and promotes autophagic flux, and simultaneously induces G2/M phase cell cycle arrest, thereby inhibiting PANC-1 cell proliferation, spheroid formation, and migration. Phanginin H can be used in research related to pancreatic ductal adenocarcinoma. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Yodsaoue O, et al. Phanginin A-K, diterpenoids from the seeds of Caesalpinia sappan Linn. Phytochemistry. 2008 Mar;69(5):1242-9.
- [2]. Su J, et al. Anti-pancreatic cancer activity of cassane diterpenoids isolated from the seeds of Caesalpinia sappan mediated by autophagy activation via ROS/AMPK/mTORC1 pathway. Phytochemistry. 2024 Jun;222:114105.
- [3]. Bao H, et al. Cytotoxic and Pro-Apoptotic Effects of Cassane Diterpenoids from the Seeds of Caesalpinia sappan in Cancer Cells. Molecules (Basel, Switzerland). 2016 Jun 18;21(6):791.
