10160-24-4
Chemical Structure
7-Bromo-1-heptanol
Synonym(s): 7-Bromoheptan-1-ol
- CAS No.: 10160-24-4
- Formula:C7H15BrO
- Molecular Weight:195.10
IUPAC Name: 7-bromoheptan-1-ol
InChIKey: MMXRRNUXCHUHOE-UHFFFAOYSA-N
SMILES: BrCCCCCCCO
Biological Activity: 7-Bromo-1-heptanol (7-Bromoheptan-1-ol) acts as a HaloTag-GPSM2 inhibitor and an organic synthesis intermediate. It forms a covalent irreversible bond with HaloTag-GPSM2, thereby blocking the subsequent labeling effect of fluorescent HaloTag ligands and enabling pulse-chase analysis of protein turnover. 7-Bromo-1-heptanol can be used to synthesize PROTAC BET degraders and multivalent glycoporphyrin antiviral compounds. It is applicable to cancer-related research[1][2][3].
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7-Bromo-1-heptanol | 99.15% | 7-Bromo-1-heptanol (7-Bromoheptan-1-ol) acts as a HaloTag-GPSM2 inhibitor and an organic synthesis intermediate. It forms a covalent irreversible bond with HaloTag-GPSM2, thereby blocking the subsequent labeling effect of fluorescent HaloTag ligands and enabling pulse-chase analysis of protein turnover. 7-Bromo-1-heptanol can be used to synthesize PROTAC BET degraders and multivalent glycoporphyrin antiviral compounds. It is applicable to cancer-related research. | ||||||||||||||||||||
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References
- [1]. Hartig EI, et al. Proteins required for stereocilia elongation during mammalian hair cell development ensure precise and steady heights during adult life. Proceedings of the National Academy of Sciences of the United States of America. 2024 Oct;121(40):e2405455121.
- [2]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. Journal of medicinal chemistry. 2018 Jan 25;61(2):462-481. [Content Brief]
- [3]. Ramos VM, et al. Mitochondrial sodium/calcium exchanger (NCLX) regulates basal and starvation-induced autophagy through calcium signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2024 Feb 15;38(3):e23454.
