102565-09-3
Chemical Structure
(E)-L-652343
- CAS No.: 102565-09-3
- Formula:C22H14F3NO2S2
- Molecular Weight:445.48
IUPAC Name: (E)-3-hydroxy-N-(2-phenyl-2-(thiophen-2-yl)vinyl)-5-(trifluoromethyl)benzo[b]thiophene-2-carboxamide
InChIKey: MWRHQMNEBAXDOF-FOWTUZBSSA-N
SMILES: O=C(C1=C(O)C2=CC(C(F)(F)F)=CC=C2S1)N/C=C(C3=CC=CC=C3)/C4=CC=CS4
Biological Activity: (E)-L-652343 is a compound with potent cyclooxygenase and 5-lipoxygenase inhibitory activity. (E)-L-652343 can effectively inhibit the synthesis of products of these two pathways in vivo. (E)-L-652343 showed high sensitivity and specificity in the detection of geometric isomers in canine and human plasma. (E)-L-652343 showed selective metabolism in vivo, and the elimination rate of the E isomer was faster than that of the Z isomer[1].
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(E)-L-652343 | (E)-L-652343 is a compound with potent cyclooxygenase and 5-lipoxygenase inhibitory activity. (E)-L-652343 can effectively inhibit the synthesis of products of these two pathways in vivo. (E)-L-652343 showed high sensitivity and specificity in the detection of geometric isomers in canine and human plasma. (E)-L-652343 showed selective metabolism in vivo, and the elimination rate of the E isomer was faster than that of the Z isomer. | |||||||||||||||||||||
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