1026582-88-6
1026582-88-6
Chemical Structure
RO-3
- CAS No.: 1026582-88-6
- Formula:C16H22N4O2
- Molecular Weight:302.37
IUPAC Name: 5-(2-isopropyl-4,5-dimethoxybenzyl)pyrimidine-2,4-diamine
InChIKey: PYNPWUIBJMVRIG-UHFFFAOYSA-N
SMILES: NC1=NC=C(CC2=CC(OC)=C(OC)C=C2C(C)C)C(N)=N1
Biological Activity: RO-3 is a potent, and orally active P2X3 and P2X2/3 antagonist with pIC50s of 5.9 and 7.0 for human homomultimeric P2X3 and heteromultimeric P2X2/3 receptors, respectively. RO-3 shows selectivity for P2X3 and P2X2/3 over all other functional homomultimeric P2X receptors (IC50 >10 μM at P2X1,2,4,5,7)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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RO-3 | 97.32% | RO-3 is a potent, and orally active P2X3 and P2X2/3 antagonist with pIC50s of 5.9 and 7.0 for human homomultimeric P2X3 and heteromultimeric P2X2/3 receptors, respectively. RO-3 shows selectivity for P2X3 and P2X2/3 over all other functional homomultimeric P2X receptors (IC50 >10 μM at P2X1,2,4,5,7). | ||||||||||||||||||||
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References
Keywords
