1030123-90-0
1030123-90-0
Chemical Structure
AEM1
- CAS No.: 1030123-90-0
- Formula:C20H14FN3O2S
- Molecular Weight:379.41
IUPAC Name: N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine
InChIKey: QGYLTGSHWIGJJD-UHFFFAOYSA-N
SMILES: FC1=CC=C(C2=CSC3=NC=NC(NCC4=CC=C(OCO5)C5=C4)=C32)C=C1
Biological Activity: AEM1 is an Nrf2 inhibitor with anti-tumor and oral activity. AEM1 promotes the differentiation of HepaRG cells towards mature liver cells, aiding in the recovery of damaged liver[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AEM1 | 99.83% | AEM1 is an Nrf2 inhibitor with anti-tumor and oral activity. AEM1 promotes the differentiation of HepaRG cells towards mature liver cells, aiding in the recovery of damaged liver. | ||||||||||||||||||||
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References
- [1]. DeNicola GM, et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature. 2011 Jul 6;475(7354):106-9. [Content Brief]
- [2]. Bollong MJ, Yun H, Sherwood L, Woods AK, Lairson LL, Schultz PG. A Small Molecule Inhibits Deregulated NRF2 Transcriptional Activity in Cancer. ACS Chem Biol. 2015 Oct 16;10(10):2193-8. [Content Brief]
Keywords
