1035154-49-4
1035154-49-4
Chemical Structure
6-Hydroxy-TSU-68
- CAS No.: 1035154-49-4
- Formula:C18H18N2O4
- Molecular Weight:326.35
IUPAC Name: (Z)-3-(5-((6-hydroxy-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrol-3-yl)propanoic acid
InChIKey: YEVBDKUJUCJAMN-ZSOIEALJSA-N
SMILES: O=C(O)CCC1=C(C)NC(/C=C2C(NC3=C\2C=CC(O)=C3)=O)=C1C
Biological Activity: 6-Hydroxy-TSU-68 is a derivative of TSU-68 (HY-10517). It is a metabolite of the biotransformation pathway of TSU-68 in human liver microsomes. The content represents the self-induced hydroxylation level of TSU-68[1].
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6-Hydroxy-TSU-68 | 6-Hydroxy-TSU-68 is a derivative of TSU-68 (HY-10517). It is a metabolite of the biotransformation pathway of TSU-68 in human liver microsomes. The content represents the self-induced hydroxylation level of TSU-68. | |||||||||||||||||||||
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References
- [1]. Ryuichi Kitamura, et al. Identification of human liver cytochrome P450 isoforms involved in autoinduced metabolism of the antiangiogenic agent (Z)-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid (TSU-68). Drug Metab Dispos. 2008 Jun;36(6):1003-9. [Content Brief]
