105017-39-8
Chemical Structure
(R,R)-Reboxetine mesylate
Synonym(s): (R,R)-FCE20124 mesylate; (R,R)-PNU155950E mesylate; (R,R)-(-)-Reboxetine mesylate
- CAS No.: 105017-39-8
- Formula:C20H27NO6S
- Molecular Weight:409.50
IUPAC Name: (R)-2-((R)-(2-ethoxyphenoxy)(phenyl)methyl)morpholine methanesulfonate
InChIKey: CGTZMJIMMUNLQD-STYNFMPRSA-N
SMILES: CCOC1=CC=CC=C1O[C@@H]([C@@]2([H])CNCCO2)C3=CC=CC=C3.CS(=O)(O)=O
Biological Activity: (R,R)-Reboxetine mesylate is an antidepressant agent with great bioavailability. (R,R)-Reboxetine is the enantiomer of Reboxetine, which is a selective noradrenaline reuptake inhibitor. Reboxetine consists of (R,R) and (S,S) enantiomer, has low affinity for alpha-adrenergic and muscarinic receptors and low toxicity in animals[1][2].
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(R,R)-Reboxetine mesylate | (R,R)-Reboxetine mesylate is an antidepressant agent with great bioavailability. (R,R)-Reboxetine is the enantiomer of Reboxetine, which is a selective noradrenaline reuptake inhibitor. Reboxetine consists of (R,R) and (S,S) enantiomer, has low affinity for alpha-adrenergic and muscarinic receptors and low toxicity in animals. | |||||||||||||||||||||
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- [1]. Wienkers LC, et al. Cytochrome P-450-mediated metabolism of the individual enantiomers of the antidepressant agent reboxetine in human liver microsomes. Drug Metab Dispos. 1999 Nov;27(11):1334-40. [Content Brief]
- [2]. Dostert P, et al. Review of the pharmacokinetics and metabolism of reboxetine, a selective noradrenaline reuptake inhibitor. Eur Neuropsychopharmacol. 1997 Apr;7 Suppl 1:S23-35; discussion S71-3. [Content Brief]
Keywords
