1062368-51-7
1062368-51-7
Chemical Structure
LDN-193688
- CAS No.: 1062368-51-7
- Formula:C22H16N4O
- Molecular Weight:352.39
InChIKey: FAOGJKJCGFIFLI-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1)C2=CN3N=CC(C4=C5C=CC=CC5=NC=C4)=C3N=C2
Biological Activity:
LDN-193688 (Compound 26) is a ALK2 inhibitor, with IC₅₀ values of 104, 18, 235, 1530, and 1080 nM against ALK1, ALK2, ALK3, ALK4, and ALK5, respectively. LDN-193688 inhibits bone morphogenetic protein 4 (BMP4)-induced phosphorylation of SMAD1/5/8, with an IC₅₀ of 2.6 μM[1][2].
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LDN-193688 | LDN-193688 (Compound 26) is a ALK2 inhibitor, with IC₅₀ values of 104, 18, 235, 1530, and 1080 nM against ALK1, ALK2, ALK3, ALK4, and ALK5, respectively. LDN-193688 inhibits bone morphogenetic protein 4 (BMP4)-induced phosphorylation of SMAD1/5/8, with an IC₅₀ of 2.6 μM. |
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References
- [1]. Mohedas AH, et al. Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem Biol. 2013;8(6):1291-1302. [Content Brief]
- [2]. Cuny GD, et al. Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg Med Chem Lett. 2008;18(15):4388-4392. [Content Brief]
Keywords
