106328-57-8
106328-57-8
Chemical Structure
BW A4C
- CAS No.: 106328-57-8
- Formula:C17H17NO3
- Molecular Weight:283.32
IUPAC Name: (E)-N-hydroxy-N-(3-(3-phenoxyphenyl)allyl)acetamide
InChIKey: CEUDWZXMLMKPNN-SOFGYWHQSA-N
SMILES: CC(N(O)C/C=C/C1=CC=CC(OC2=CC=CC=C2)=C1)=O
Biological Activity: BW A4C is a selective 5-lipoxygenase (5-LO) inhibitor. BW A4C is also an inhibitor of linoleic acid 8R-dioxygenase in Gaeumannomyces graminis, with an IC50 value of 0.2 μM. BW A4C can be used in research on diseases such as asthma[1][2].
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BW A4C | BW A4C is a selective 5-lipoxygenase (5-LO) inhibitor. BW A4C is also an inhibitor of linoleic acid 8R-dioxygenase in Gaeumannomyces graminis, with an IC50 value of 0.2 μM. BW A4C can be used in research on diseases such as asthma. | |||||||||||||||||||||
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References
- [1]. Payne AN, et al. Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. Agents Actions Suppl. 1991;34:189-99. [Content Brief]
- [2]. Brodowsky ID, et al. BW A4C and other hydroxamic acids are potent inhibitors of linoleic acid 8R-dioxygenase of the fungus Gaeumannomyces graminis. Eur J Pharmacol. 1994 Mar 11;254(1-2):43-7. [Content Brief]
