106410-13-3
106410-13-3
Chemical Structure
NSC 140873
- CAS No.: 106410-13-3
- Formula:C13H12ClN3O2
- Molecular Weight:277.71
IUPAC Name: 2-amino-N-(4-chloro-2-(1H-pyrrole-2-carbonyl)phenyl)acetamide
InChIKey: HEMNVSCJOZIBEQ-UHFFFAOYSA-N
SMILES: ClC1=CC(C(C2=CC=CN2)=O)=C(NC(CN)=O)C=C1
Biological Activity: NSC 140873 is an inhibitor of the RUNX1-CBFβ interaction. NSC 140873 can be used for research of viral infection and leukemia. NSC 140873 has an unstable structure and can be converted spontaneously in solution to a benzodiazepine (Ro5-3335)[1][2].
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NSC 140873 | NSC 140873 is an inhibitor of the RUNX1-CBFβ interaction. NSC 140873 can be used for research of viral infection and leukemia. NSC 140873 has an unstable structure and can be converted spontaneously in solution to a benzodiazepine (Ro5-3335). | |||||||||||||||||||||
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References
- [1]. Pu Liu, et al. Methods for treating leukemia and disorders mediated by cbfβ and runx1 proteins. Patent. WO2012125787A1.
- [2]. Cunningham L, et al. Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14592-7. [Content Brief]
