1070878-63-5
Chemical Structure
Flortanidazole
- CAS No.: 1070878-63-5
- Formula:C9H11FN6O3
- Molecular Weight:270.22
IUPAC Name: 3-fluoro-2-(4-((2-nitro-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)propan-1-ol
InChIKey: ZSSPATINHRVRTN-UHFFFAOYSA-N
SMILES: OCC(CF)N1N=NC(CN2C=CN=C2[N+]([O-])=O)=C1
Biological Activity: Flortanidazole is a derivative of 2-Nitroimidazole (HY-N0195). Under hypoxic conditions, Flortanidazole accumulates in hypoxic tissues through the reduction of 2-nitroimidazole and the retention of reactive intermediates by viable hypoxic cells. Flortanidazole binds to intracellular macromolecules under hypoxic conditions, thereby enabling quantification of tumor hypoxia. [18F]Flortanidazole, formed after labeling Flortanidazole with 18F, is a hypoxic PET imaging tracer and prognostic imaging biomarker. Flortanidazole can be used in the study of non-small cell lung cancer and colorectal cancer[1][2].
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Flortanidazole | Flortanidazole is a derivative of 2-Nitroimidazole (HY-N0195). Under hypoxic conditions, Flortanidazole accumulates in hypoxic tissues through the reduction of 2-nitroimidazole and the retention of reactive intermediates by viable hypoxic cells. Flortanidazole binds to intracellular macromolecules under hypoxic conditions, thereby enabling quantification of tumor hypoxia. [18F]Flortanidazole, formed after labeling Flortanidazole with 18F, is a hypoxic PET imaging tracer and prognostic imaging biomarker. Flortanidazole can be used in the study of non-small cell lung cancer and colorectal cancer. | |||||||||||||||||||||
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References
- [1]. De Bruycker S, et al. F-Flortanidazole Hypoxia PET Holds Promise as a Prognostic and Predictive Imaging Biomarker in a Lung Cancer Xenograft Model Treated with Metformin and Radiotherapy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2019 Jan;60(1):34-40.
- [2]. De Bruycker S, et al. Effects of metformin on tumor hypoxia and radiotherapy efficacy: a [F]HX4 PET imaging study in colorectal cancer xenografts. EJNMMI research. 2019 Aug 02;9(1):74.
