1070966-96-9
Chemical Structure
BKM1644
- CAS No.: 1070966-96-9
- Formula:C34H37Cl2F5N2O9P2
- Molecular Weight:845.51
IUPAC Name: tetraethyl ((3-(4-((2,6-dichlorobenzyl)oxy)phenyl)-2-(3-(perfluorophenyl)acrylamido)propanamido)methylene)(R,E)-bis(phosphonate)
InChIKey: BUVQOTXMGBNZPM-ZMNABIIRSA-N
SMILES: O=C(/C=C/C1=C(C(F)=C(C(F)=C1F)F)F)N[C@@H](C(NC(P(OCC)(OCC)=O)P(OCC)(OCC)=O)=O)CC2=CC=C(C=C2)OCC3=C(C=CC=C3Cl)Cl
Biological Activity: BKM1644, an acyl-tyrosine bisphosphonate amide derivative, exhibits potent anti-cancer activity. BKM1644 effectively inhibits the proliferation of metastatic, castration-resistant prostate cance (mCRPC) cells. BKM1644 sensitizes mCRPC cells to Docetaxel (HY-B0011) and retards the bone metastatic growth of prostate cance[1].
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BKM1644 | BKM1644, an acyl-tyrosine bisphosphonate amide derivative, exhibits potent anti-cancer activity. BKM1644 effectively inhibits the proliferation of metastatic, castration-resistant prostate cance (mCRPC) cells. BKM1644 sensitizes mCRPC cells to Docetaxel (HY-B0011) and retards the bone metastatic growth of prostate cance. | |||||||||||||||||||||
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