109434-21-1
Chemical Structure
Adenosine 3'-phosphate 5'-phosphosulfate lithium
- CAS No.: 109434-21-1
- Formula:C10H15N5O13P2S.xLi
- Molecular Weight:N/A
SMILES: O[C@H]1[C@](O[C@@H]([C@H]1O)COP(OS(=O)(O)=O)(O)=O)([H])N2C3=NC=NC(NP(O)(O)=O)=C3N=C2.[Li].[x]
Biological Activity: Adenosine 3'-phosphate 5'-phosphosulfate lithium, an adenine nucleotide derivative, is a selective P2Y1 antagonist with no effect on P2Y2, P2Y4, or P2Y6 receptors. Adenosine 3'-phosphate 5'-phosphosulfate lithium can competitive inhibit ADP-induced platelet aggregation, as well as the ability of ADP to cause shape change and increases in Ca2+ in platelets, but had no effect on the inhibition of stimulated adenylate cyclase by ADP. Adenosine 3'-phosphate 5'-phosphosulfate lithium is a co-substrate used for the sulfonation of glycans. Adenosine 3'-phosphate 5'-phosphosulfate lithium can be used for Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase assays, which as donor substrate to transfer a sulfonate group[1][2][3].
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Adenosine 3'-phosphate 5'-phosphosulfate lithium | Adenosine 3'-phosphate 5'-phosphosulfate lithium, an adenine nucleotide derivative, is a selective P2Y1 antagonist with no effect on P2Y2, P2Y4, or P2Y6 receptors. Adenosine 3'-phosphate 5'-phosphosulfate lithium can competitive inhibit ADP-induced platelet aggregation, as well as the ability of ADP to cause shape change and increases in Ca2+ in platelets, but had no effect on the inhibition of stimulated adenylate cyclase by ADP. Adenosine 3'-phosphate 5'-phosphosulfate lithium is a co-substrate used for the sulfonation of glycans. Adenosine 3'-phosphate 5'-phosphosulfate lithium can be used for Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase assays, which as donor substrate to transfer a sulfonate group. | |||||||||||||||||||||
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References
- [1]. Prather B, et, al. Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase assays. Anal Biochem. 2012 Apr 1;423(1):86-92. [Content Brief]
- [2]. Ryan P. Modified indole alkaloids for therapeutic uses. WO2022133314.
- [3]. Park H S, et al. Effects of adenosine 3′‐phosphate 5′‐phosphosulfate on P2 receptors in platelets and smooth muscle preparations[J]. Drug development research, 1998, 45(2): 67-73.
