110763-24-1
Chemical Structure
VPC-3033
- CAS No.: 110763-24-1
- Formula:C21H14O2
- Molecular Weight:298.33
IUPAC Name: 10-(3-hydroxybenzylidene)anthracen-9(10H)-one
InChIKey: KGQNBZACENOOOR-UHFFFAOYSA-N
SMILES: O=C1C2=C(/C(C3=C1C=CC=C3)=C\C4=CC(O)=CC=C4)C=CC=C2
Biological Activity: VPC-3033 is an androgen receptor antagonist. VPC-3033 has a strong androgen DHT replacement potency (IC50: 0.625-2.5 μM), can effectively inhibit androgen receptor transcriptional activity (IC50=0.3 μM), and has a strong androgen receptor degradation ability. In addition, VPC-3033 exhibits significant anti-androgen receptor activity against prostate cancer cells resistant to Enzalutamide (HY-70002)[1].
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VPC-3033 | VPC-3033 is an androgen receptor antagonist. VPC-3033 has a strong androgen DHT replacement potency (IC50: 0.625-2.5 μM), can effectively inhibit androgen receptor transcriptional activity (IC50=0.3 μM), and has a strong androgen receptor degradation ability. In addition, VPC-3033 exhibits significant anti-androgen receptor activity against prostate cancer cells resistant to Enzalutamide (HY-70002). | |||||||||||||||||||||
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Keywords
