1125746-49-7
Chemical Structure
KLYP961
- CAS No.: 1125746-49-7
- Formula:C19H15F2N5O
- Molecular Weight:367.35
IUPAC Name: 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one
InChIKey: ISGGXCWQSOCOCW-UHFFFAOYSA-N
SMILES: O=C1C=C(CN2C3=C(N=C2C4CCC4)N=CC=N3)C5=C(N1)C(F)=C(F)C=C5
Biological Activity: KLYP961 is a selective and orally active dual inhibitor of inducible and neuronal NO synthase (IC50 = 50-400 nM). KLYP961 can inhibit endotoxin-evoked plasma nitrates increases and attenuate pain behaviors in a mouse formalin model. KLYP961 can attenuate carrageenin-induced edema and inflammatory hyperalgesia and writhing response elicited by Phenylbenzoquinone (HY-W275039). KLYP961 can be used for the research of neurological disease[1].
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KLYP961 | KLYP961 is a selective and orally active dual inhibitor of inducible and neuronal NO synthase (IC50 = 50-400 nM). KLYP961 can inhibit endotoxin-evoked plasma nitrates increases and attenuate pain behaviors in a mouse formalin model. KLYP961 can attenuate carrageenin-induced edema and inflammatory hyperalgesia and writhing response elicited by Phenylbenzoquinone (HY-W275039). KLYP961 can be used for the research of neurological disease. | |||||||||||||||||||||
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