1135306-29-4
Chemical Structure
6-Bnz-cAMP sodium salt
- CAS No.: 1135306-29-4
- Formula:C17H15N5NaO7P
- Molecular Weight:455.29
IUPAC Name: sodium (4aR,6R,7R,7aS)-6-(6-benzamido-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide
InChIKey: SPYGSKQRPXISIB-FKVBDRBCSA-M
SMILES: O[C@@H]1[C@H](OP2(O[Na])=O)[C@@H](CO2)O[C@H]1N3C=NC4=C3N=CN=C4NC(C5=CC=CC=C5)=O
Biological Activity: 6-Bnz-cAMP sodium, a derivative of cyclic adenosine monophosphate (cAMP), is a selective PKA activator with inhibitory activity against the bTREK-1 K+ channel. 6-Bnz-cAMP sodium does not activate the Epac signaling pathway. It inhibits the bTREK-1 K+ channel via a voltage-independent, ATP-dependent mechanism that is independent of the PKA/Epac/calmodulin kinase/MAP kinase pathway. 6-Bnz-cAMP sodium activates CREB phosphorylation to regulate osteoblast-specific gene expression, induces osteoblast differentiation, promotes extracellular matrix mineralization, supports osteoblast proliferation, and shows no cytotoxicity toward osteoblasts. It can be used in studies related to bone tissue repair and regeneration[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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6-Bnz-cAMP sodium salt | 98.5% | 6-Bnz-cAMP sodium, a derivative of cyclic adenosine monophosphate (cAMP), is a selective PKA activator with inhibitory activity against the bTREK-1 K+ channel. 6-Bnz-cAMP sodium does not activate the Epac signaling pathway. It inhibits the bTREK-1 K+ channel via a voltage-independent, ATP-dependent mechanism that is independent of the PKA/Epac/calmodulin kinase/MAP kinase pathway. 6-Bnz-cAMP sodium activates CREB phosphorylation to regulate osteoblast-specific gene expression, induces osteoblast differentiation, promotes extracellular matrix mineralization, supports osteoblast proliferation, and shows no cytotoxicity toward osteoblasts. It can be used in studies related to bone tissue repair and regeneration. | ||||||||||||||||||||
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- [1]. Hayashi M, et al. Actions of cAMP on calcium sensitization in human detrusor smooth muscle contraction. BJU Int. 2016;117(1):179-191. [Content Brief]
- [2]. Liu H, et al. N6-substituted cAMP analogs inhibit bTREK-1 K+ channels and stimulate cortisol secretion by a protein kinase A-independent mechanism. Mol Pharmacol. 2009;76(6):1290-1301. [Content Brief]
- [3]. Lo KW, et al. The small molecule PKA-specific cyclic AMP analogue as an inducer of osteoblast-like cells differentiation and mineralization. J Tissue Eng Regen Med. 2012;6(1):40-48. [Content Brief]
Keywords
