1141777-14-1
1141777-14-1
Chemical Structure
Emixustat
Synonym(s): ACU-4429
- CAS No.: 1141777-14-1
- Formula:C16H25NO2
- Molecular Weight:263.38
IUPAC Name: (R)-3-amino-1-(3-(cyclohexylmethoxy)phenyl)propan-1-ol
InChIKey: WJIGGYYSZBWCGC-MRXNPFEDSA-N
SMILES: O[C@H](CCN)C1=CC(OCC2CCCCC2)=CC=C1
Biological Activity: Emixustat is an orally active RPE65 inhibitor with an IC50 value of 4.4 nM. Emixustat is also a visual cycle modulator, capable of regulating visual cycle activity by inhibiting retinol isomerization, and holds potential for studying vision disorders such as age-related macular degeneration (AMD)[1][2][3][4].
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Emixustat | 98.17% | Emixustat is an orally active RPE65 inhibitor with an IC50 value of 4.4 nM. Emixustat is also a visual cycle modulator, capable of regulating visual cycle activity by inhibiting retinol isomerization, and holds potential for studying vision disorders such as age-related macular degeneration (AMD). | ||||||||||||||||||||
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References
- [1]. Bavik C, et al. Visual Cycle Modulation as an Approach toward Preservation of Retinal Integrity. PLoS One. 2015 May 13;10(5):e0124940. [Content Brief]
- [2]. Kiser PD, et al. Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat Chem Biol. 2015 Jun;11(6):409-15. [Content Brief]
- [3]. Kubota R, et al. Emixustat Reduces Metabolic Demand of Dark Activity in the Retina. Invest Ophthalmol Vis Sci. 2019 Nov 1;60(14):4924-4930. [Content Brief]
- [4]. Bavik C, et al. Visual Cycle Modulation as an Approach toward Preservation of Retinal Integrity. PLoS One. 2015 May 13;10(5):e0124940. [Content Brief]
