1146541-45-8
1146541-45-8
Chemical Structure
ODN 2088
- CAS No.: 1146541-45-8
- Formula:N/A
- Molecular Weight:4878.00
SMILES: [DNA, d(P-thio)(T-C-C-T-G-G-C-G-G-G-G-A-A-G-T)]
Biological Activity: ODN 2088 is a potent TLR3, TLR7 and TLR9 inhibitor. ODN 2088 shows no cytotoxic. ODN 2088 inhibits the release of IFN-α and IL-6[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ODN 2088 | 94.50% | ODN 2088 is a potent TLR3, TLR7 and TLR9 inhibitor. ODN 2088 shows no cytotoxic. ODN 2088 inhibits the release of IFN-α and IL-6. | ||||||||||||||||||||
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References
- [1]. Römmler F, et al. Guanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated immune responses of human immune cells. PLoS One. 2015 Feb 19;10(2):e0116703. [Content Brief]
- [2]. Duramad O, et al. Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation. J Immunol. 2005 May 1;174(9):5193-200. [Content Brief]
- [3]. Römmler F, et al. Guanine modification of inhibitory oligonucleotides potentiates their suppressive function. J Immunol. 2013 Sep 15;191(6):3240-53. [Content Brief]
