1146629-86-8
Chemical Structure
Varlitinib tosylate
Synonym(s): ASLAN001 tosylate; ARRY-334543 tosylate
- CAS No.: 1146629-86-8
- Formula:C36H35ClN6O8S3
- Molecular Weight:811.35
IUPAC Name: (R)-N4-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6-(4-methyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine bis(4-methylbenzenesulfonate)
InChIKey: QSUPQMGDXOHVLK-FFXKMJQXSA-N
SMILES: C[C@H]1N=C(NC2=CC3=C(NC4=CC=C(OCC5=NC=CS5)C(Cl)=C4)N=CN=C3C=C2)OC1.O=S(C6=CC=C(C=C6)C)(O)=O.O=S(C7=CC=C(C=C7)C)(O)=O
Biological Activity: Varlitinib (ASLAN001) tosylate is a potent, reversible, small molecule pan-EGFR inhibitor with IC50s of 7, 2, 4 nM for HER1, HER2 and HER4, respectively[1].
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Varlitinib tosylate | Varlitinib (ASLAN001) tosylate is a potent, reversible, small molecule pan-EGFR inhibitor with IC50s of 7, 2, 4 nM for HER1, HER2 and HER4, respectively. | |||||||||||||||||||||
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Keywords
