1159101-48-0
Chemical Structure
Tarafenacin D-tartrate
Synonym(s): SVT-40776 D-tartrate
- CAS No.: 1159101-48-0
- Formula:C25H26F4N2O8
- Molecular Weight:558.48
IUPAC Name: (R)-quinuclidin-3-yl (3-fluorophenyl)(3,4,5-trifluorobenzyl)carbamate (2S,3S)-2,3-dihydroxysuccinate
InChIKey: YJBKAMMKXVRSAI-CUCKRJOPSA-N
SMILES: O=C(O[C@H]1CN2CCC1CC2)N(C3=CC=CC(F)=C3)CC4=CC(F)=C(F)C(F)=C4.O[C@@H]([C@@H](C(O)=O)O)C(O)=O
Biological Activity: Tarafenacin (SVT-40776) D-tartrate is an orally active, selective M3 muscarinic receptor (M3 muscarinic receptor) antagonist with 203-fold selectivity over the M2 muscarinic receptor. Tarafenacin D-tartrate does not affect atrial contraction, arterial blood pressure or arterial pressure at high doses. Tarafenacin D-tartrate can be used in the research of overactive bladder[1][2][3].
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Tarafenacin D-tartrate | 99.75% | Tarafenacin (SVT-40776) D-tartrate is an orally active, selective M3 muscarinic receptor (M3 muscarinic receptor) antagonist with 203-fold selectivity over the M2 muscarinic receptor. Tarafenacin D-tartrate does not affect atrial contraction, arterial blood pressure or arterial pressure at high doses. Tarafenacin D-tartrate can be used in the research of overactive bladder. | ||||||||||||||||||||
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- [1]. Salcedo C, et al. In vivo and in vitro pharmacological characterization of SVT-40776, a novel M3 muscarinic receptor antagonist, for the treatment of overactive bladder. Br J Pharmacol. 2009;156(5):807-817. [Content Brief]
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[2]. Balsa D, et al. FUNCTIONAL BLADDER SELECTIVITY OF SVT-40776: A COMPARATIVE
STUDY. - [3]. Huang X, et al. Microscopic binding of M5 muscarinic acetylcholine receptor with antagonists by homology modeling, molecular docking, and molecular dynamics simulation. J Phys Chem B. 2012;116(1):532-541. [Content Brief]
Keywords
