1184300-63-7
1184300-63-7
Chemical Structure
SAR107375
- CAS No.: 1184300-63-7
- Formula:C24H30ClN5O5S2
- Molecular Weight:568.11
IUPAC Name: (S)-5-chloro-N-(2-(2-methyl-3-(2-oxopyrrolidin-1-yl)phenylsulfonamido)-3-(4-methylpiperazin-1-yl)-3-oxopropyl)thiophene-2-carboxamide
InChIKey: CYVVCTRDWISRAC-KRWDZBQOSA-N
SMILES: O=C(C1=CC=C(Cl)S1)NC[C@H](NS(=O)(C2=CC=CC(N3C(CCC3)=O)=C2C)=O)C(N4CCN(C)CC4)=O
Biological Activity: SAR107375 is a potent and orally active dual thrombin and factor Xa inhibitor, with Ki values of 1 nM and 8 nM for factor Xa and thrombin, respectively[1].
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SAR107375 | SAR107375 is a potent and orally active dual thrombin and factor Xa inhibitor, with Ki values of 1 nM and 8 nM for factor Xa and thrombin, respectively. | |||||||||||||||||||||
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SAR107375-d11 Tartrate | SAR107375-d11 (Tartrate) is deuterium labeled SAR107375. SAR107375 is a potent and orally active dual thrombin and factor Xa inhibitor, with Ki values of 1 nM and 8 nM for factor Xa and thrombin, respectively. | |||||||||||||||||||||
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References
- [1]. Jerome Meneyrol, et al. 5-Chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide (SAR107375), a selective and potent orally active dual thrombin and factor Xa inhibitor. J Med Chem. 2013 Dec 12;56(23):9441-56. [Content Brief]
Keywords
