1191043-85-2
Chemical Structure
Dendrogenin A
Synonym(s): DDA
- CAS. Nr.: 1191043-85-2
- Formula:C32H55N3O2
- Molecular Weight:513.80
IUPAC Name: (3S,5R,6R,8S,9S,10R,13R,14S,17R)-6-((2-(1H-imidazol-5-yl)ethyl)amino)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)hexadecahydro-5H-cyclopenta[a]phenanthrene-3,5-diol
InChIKey: AVFNYTPENXWWCA-BULFVYHESA-N
SMILES: C[C@@]12[C@]3([H])[C@](C[C@H]([C@]1(C[C@H](CC2)O)O)NCCC4=CN=CN4)([H])[C@@]5([H])[C@](CC3)([C@@](CC5)([H])[C@H](C)CCCC(C)C)C
Biological Activity: Dendrogenin A (DDA) is a ligand for liver X receptor (LXR), that induces the expression of sodium/iodine symporter, and increases iodine uptake. Dendrogenin A induces cell differentiation of MCF-7, and reactivates the function of lactating cells. Dendrogenin A induces the expressions of the TSH receptor, thyroid peroxidase, and thyroglobulin, and affects thyroid hormone generation. Dendrogenin A exhibits cytotoxicity in cancer cell B-CPAP and 8505c with IC50 of 4.1 and 6.2 µM. Dendrogenin A arrests the cell cycle at G0/G1 phase[1].
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Dendrogenin A | 96.74% | Dendrogenin A (DDA) is a ligand for liver X receptor (LXR), that induces the expression of sodium/iodine symporter, and increases iodine uptake. Dendrogenin A induces cell differentiation of MCF-7, and reactivates the function of lactating cells. Dendrogenin A induces the expressions of the TSH receptor, thyroid peroxidase, and thyroglobulin, and affects thyroid hormone generation. Dendrogenin A exhibits cytotoxicity in cancer cell B-CPAP and 8505c with IC50 of 4.1 and 6.2 µM. Dendrogenin A arrests the cell cycle at G0/G1 phase. | ||||||||||||||||||||
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